Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R) promotes
the differentiation of myeloid progenitors into heterogeneous populations of monocytes, …

With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–mobilized
peripheral blood stem cell donor grafts and successful treatment of older …

The last 6 decades have seen major advances in the understanding of immunologic diseases,
driven by preclinical animal models. Indeed, bone marrow transplantation (BMT) has its …

Dendritic cells (DCs) are key antigen-presenting cells for stimulating immune responses and
they are now being investigated in clinical settings. Although defined as lineage-negative (…

The development of the mononuclear phagocyte system requires macrophage colony-stimulating
factor (CSF-1) signaling through the CSF-1 receptor (CSF1R, CD115). We examined …

Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

The presentation pathways by which allogeneic peptides induce graft-versus-host disease (GVHD)
are unclear. We developed a bone marrow transplant (BMT) system in mice whereby …

Background Interleukin 6 mediates graft-versus-host disease (GVHD) in experimental
allogeneic stem-cell transplantation (allogeneic SCT) and represents an attractive therapeutic …

Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell
transplantation and characteristically develops in organs such as skin and lung. Here, we used …

DEC-205 (CD205) belongs to the macrophage mannose receptor family of C-type lectin
endocytic receptors and behaves as an antigen uptake/processing receptor for dendritic cells (…