Transcription of developmental genes is controlled by multiple enhancers. Frequently, more
than one enhancer can activate transcription from the same promoter in the same cells. How …

3005 Background: SHP2 transduces signals from activated receptor tyrosine kinases to
downstream pathways including MAPK. TNO155 is a selective, allosteric, oral inhibitor of SHP2. …

The amyloid β-peptide (Aβ) of Alzheimer’s disease (AD) is generated by proteolysis within
the transmembrane domain (TMD) of a C-terminal fragment of the amyloid β protein-precursor …

Hunchback is a bifunctional transcription factor that can activate and repress gene expression
in Drosophila development. We investigated the regulatory DNA sequence features that …

Copy number heterogeneity is a prominent feature within tumors. The molecular basis for
this heterogeneity remains poorly characterized. Here, we demonstrate that hypoxia induces …

The National Institutes of Health (NIH) encourages trainees to make Individualized Development
Plans to help them prepare for academic and nonacademic careers. We describe our …

Transcription factors (TFs) control gene expression, often acting synergistically. Classical
thermodynamic models offer a biophysical explanation for synergy based on binding …

Computational models of enhancer function generally assume that transcription factors (TFs)
exert their regulatory effects independently, modeling an enhancer as a "bag of sites." …

METHODS• Assess the efficacy of co-localized biomarkers on EVs in discriminating between
normal healthy samples and patients with benign adnexal masses from early HGSOC …

Background Hydrophobic interaction chromatography (HIC) most commonly requires experimental
determination (ie, scouting) in order to select an optimal chromatographic medium for …