Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally exhibit …

Human skin harbors two major T cell compartments of equal size that are distinguished by
expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 …

Adaptive immunity requires the generation of memory T cells from naive precursors selected
in the thymus. The key intermediaries in this process are stem cell-like memory T (T SCM ) …

Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence.
Without immune pressure, laboratory-adapted HCMV strains have undergone genetic …

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2 + semi-invariant
TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites …

Adaptive immunity relies on the generation and maintenance of memory T cells to provide
protection against repeated antigen exposure. It has been hypothesised that a self-renewing …

The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-recognition
of a major histocompatibility complex molecule and its carried peptide. However, …

Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is
enabled by its remarkable capacity to systematically subvert host immune defenses. In …

T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify
a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These …

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following
congenital infection and in immunocompromised individuals. No vaccines are licensed, …