Synthesis of new fluorogenic cyanine dyes and incorporation into RNA fluoromodules
TP Constantin, GL Silva, KL Robertson… - Organic …, 2008 - ACS Publications
A new fluorogenic cyanine dye was synthesized and found to have low fluorescence quantum
yield in fluid solution and in the presence of double-stranded DNA but 80-fold enhanced …
yield in fluid solution and in the presence of double-stranded DNA but 80-fold enhanced …
[HTML][HTML] Adaptation of the Black Yeast Wangiella dermatitidis to Ionizing Radiation: Molecular and Cellular Mechanisms
Observations of enhanced growth of melanized fungi under low-dose ionizing radiation in
the laboratory and in the damaged Chernobyl nuclear reactor suggest they have adapted the …
the laboratory and in the damaged Chernobyl nuclear reactor suggest they have adapted the …
[HTML][HTML] Function and Regulation of Vibrio campbellii Proteorhodopsin: Acquired Phototrophy in a Classical Organoheterotroph
…, CM Soto, AM Rahbar, KL Robertson… - PLoS …, 2012 - journals.plos.org
Proteorhodopsins (PRs) are retinal-binding photoproteins that mediate light-driven proton
translocation across prokaryotic cell membranes. Despite their abundance, wide distribution …
translocation across prokaryotic cell membranes. Despite their abundance, wide distribution …
Blue fluorescent dye-protein complexes based on fluorogenic cyanine dyes and single chain antibody fragments
…, GL Silva, Y Creeger, KL Robertson… - Organic & …, 2011 - pubs.rsc.org
Fluoromodules are complexes formed upon the noncovalent binding of a fluorogenic dye to
its cognate biomolecular partner, which significantly enhances the fluorescence quantum …
its cognate biomolecular partner, which significantly enhances the fluorescence quantum …
Engineered T4 viral nanoparticles for cellular imaging and flow cytometry
KL Robertson, CM Soto, MJ Archer… - Bioconjugate …, 2011 - ACS Publications
Viruses are of particular interest as scaffolds for biotechnology applications given their wide
range of shapes and sizes and the possibility to modify them with a variety of functional …
range of shapes and sizes and the possibility to modify them with a variety of functional …
Probing the donor and acceptor substrate specificity of the γ-glutamyl transpeptidase
…, A Scorpio, JR Compton, KL Robertson… - Biochemistry, 2012 - ACS Publications
γ-Glutamyl transpeptidase (GGT) is a two-substrate enzyme that plays a central role in
glutathione metabolism and is a potential target for drug design. GGT catalyzes the cleavage of γ-…
glutathione metabolism and is a potential target for drug design. GGT catalyzes the cleavage of γ-…
[HTML][HTML] Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner
SS Lellupitiyage Don, KL Robertson, HH Lin… - PLoS …, 2020 - journals.plos.org
The natural product nobiletin is a small molecule, widely studied with regard to its therapeutic
effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown …
effects, including in cancer cell lines and tumors. Recently, nobiletin has also been shown …
Fluorescent PNA probes as hybridization labels for biological RNA
KL Robertson, L Yu, BA Armitage, AJ Lopez… - Biochemistry, 2006 - ACS Publications
Fluorescent labeling of biological RNA is complicated by the narrow range of nucleoside
triphosphates that can be used for biological synthesis (ie, transcription) as well as the inability …
triphosphates that can be used for biological synthesis (ie, transcription) as well as the inability …
Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression
JL Liu, AB Dixit, KL Robertson… - Proceedings of the …, 2014 - National Acad Sciences
Packaging specific exogenous active proteins and DNAs together within a single viral-nanocontainer
is challenging. The bacteriophage T4 capsid (100 × 70 nm) is well suited for this …
is challenging. The bacteriophage T4 capsid (100 × 70 nm) is well suited for this …
LNA flow–FISH: a flow cytometry–fluorescence in situ hybridization method to detect messenger RNA using locked nucleic acid probes
KL Robertson, DC Thach - Analytical biochemistry, 2009 - Elsevier
We present a novel method using flow cytometry–fluorescence in situ hybridization (flow–FISH)
to detect specific messenger RNA (mRNA) in suspended cells using locked nucleic acid (…
to detect specific messenger RNA (mRNA) in suspended cells using locked nucleic acid (…