Swine influenza viruses: a North American perspective

AL Vincent, W Ma, KM Lager, BH Janke… - Advances in virus …, 2008 - Elsevier
Influenza is a zoonotic viral disease that represents a health and economic threat to both
humans and animals worldwide. Swine influenza (SI) was first recognized clinically in pigs in …

Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs

A Solórzano, RJ Webby, KM Lager, BH Janke… - Journal of …, 2005 - Am Soc Microbiol
It has been shown previously that the nonstructural protein NS1 of influenza virus is an
alpha/beta interferon (IFN-α/β) antagonist, both in vitro and in experimental animal model systems…

Identification of H2N3 influenza A viruses from swine in the United States

…, MR Gramer, CB Brockwell, KM Lager… - Proceedings of the …, 2007 - National Acad Sciences
Although viruses of each of the 16 influenza A HA subtypes are potential human pathogens,
only viruses of the H1, H2, and H3 subtype are known to have been successfully …

Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States

AL Vincent, W Ma, KM Lager, MR Gramer, JA Richt… - Virus genes, 2009 - Springer
H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified
in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the …

Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine

JA Richt, P Lekcharoensuk, KM Lager… - Journal of …, 2006 - Am Soc Microbiol
Swine influenza viruses (SIV) naturally infect pigs and can be transmitted to humans. In the
pig, genetic reassortment to create novel influenza subtypes by mixing avian, human, and …

Pathogenic and antigenic properties of phylogenetically distinct reassortant H3N2 swine influenza viruses cocirculating in the United States

JA Richt, KM Lager, BH Janke, RD Woods… - Journal of clinical …, 2003 - Am Soc Microbiol
Swine influenza is an acute respiratory disease caused by type A influenza viruses. Before
1998, swine influenza virus isolates in the United States were mainly of the classical H1N1 …

Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts

SN Langel, FC Paim, KM Lager, AN Vlasova, LJ Saif - Virus research, 2016 - Elsevier
Morbidity, mortality, and loss of productivity from enteric diseases in neonatal piglets cost
swine producers millions of dollars annually. In 2013–2014, the porcine epidemic diarrhea …

Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of “atypical” PRRS

WL Mengeling, KM Lager… - American journal of …, 1998 - Am Vet Med Assoc
Objective To determine clinical consequences of exposing pregnant gilts to strains of porcine
reproductive and respiratory syndrome (PRRS) virus (PRRSV) isolated from field cases of “…

Differentiation of a porcine reproductive and respiratory syndrome virus vaccine strain from North American field strains by restriction fragment length polymorphism …

RD Wesley, WL Mengeling, KM Lager… - Journal of …, 1998 - journals.sagepub.com
The suitability of restriction fragment length polymorphism (RFLP) analysis for differentiating
a porcine reproductive and respiratory syndrome virus (PRRSV) vaccine strain from other …

Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008

…, CA Russell, DJ Smith, KM Lager… - Journal of General …, 2011 - microbiologyresearch.org
Prior to the introduction of the 2009 pandemic H1N1 virus from humans into pigs, four
phylogenetic clusters (α-, β-, γ- and δ) of the haemagglutinin (HA) gene from H1 influenza viruses …