Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for
millisecond resolution control of neural activity. By targeting opsin expression to specific cell …

Runx3/Pebp2αC null mouse gastric mucosa exhibits hyperplasias due to stimulated
proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to growth-…

Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process
requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can …

The differentiation of mesenchymal cells into chondrocytes and chondrocyte proliferation
and maturation are fundamental steps in skeletal development. Runx2 is essential for …

Runt-related (Runx) transcription factors control diverse aspects of embryonic development
and are responsible for the pathogenesis of many human diseases. In recent years, the …

Background In preimplantation mouse embryos, the first cell fate specification to the
trophectoderm or inner cell mass occurs by the early blastocyst stage. The cell fate is controlled by …

Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral
targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are …

The lentiviral vector system is used extensively in gene therapy trials for various neurological
and neurodegenerative disorders. The vector system permits efficient and sustained gene …

A series of conditional reporter mouse lines were established in which specific organelles
were labeled with fluorescent proteins. Subcellular localization and intensity of 28 fluorescent …

The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs)
afford remotely reversible control of cellular signaling, neuronal activity and …