Integrated strategy for lead optimization based on fragment growing: the diversity-oriented-target-focused-synthesis approach
Over the past few decades, hit identification has been greatly facilitated by advances in high-throughput
and fragment-based screenings. One major hurdle remaining in drug discovery …
and fragment-based screenings. One major hurdle remaining in drug discovery …
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
J Ariey‐Bonnet, K Carrasco, M Le Grand… - Molecular …, 2020 - Wiley Online Library
The concept of polypharmacology involves the interaction of drug molecules with multiple
molecular targets. It provides a unique opportunity for the repurposing of already‐approved …
molecular targets. It provides a unique opportunity for the repurposing of already‐approved …
CRCM5484: A BET-BDII selective compound with differential anti-leukemic drug modulation
K Carrasco, C Montersino, C Derviaux… - Journal of Medicinal …, 2022 - ACS Publications
Differentially screening the Fr-PPIChem chemical library on the bromodomain and extra-terminal
(BET) BRD4-BDII versus -BDI bromodomains led to the discovery of a BDII-selective …
(BET) BRD4-BDII versus -BDI bromodomains led to the discovery of a BDII-selective …
PDZome-wide and structural characterization of the PDZ-binding motif of VANGL2
M Montserrat-Gomez, G Gogl, K Carrasco… - … et Biophysica Acta (BBA …, 2024 - Elsevier
VANGL2 is a core component of the non-canonical Wnt/Planar Cell Polarity signaling pathway
that uses its highly conserved carboxy-terminal type 1 PDZ-binding motif (PBM) to bind a …
that uses its highly conserved carboxy-terminal type 1 PDZ-binding motif (PBM) to bind a …
Spatio-temporal co-occurrence of hotspots of tuberculosis, poverty and air pollution in Lima, Peru
G Carrasco-Escobar, A Schwalb… - Infectious Diseases of …, 2020 - mednexus.org
… Kendall’s W test was performed to evaluate the co-occurrence between cluster categories
of TB cases, poverty, and PM 2.5 as previously described [22]. Kendall’s W measure the …
of TB cases, poverty, and PM 2.5 as previously described [22]. Kendall’s W measure the …
Estimating the generalized concordance correlation coefficient through variance components
JL Carrasco, L Jover - Biometrics, 2003 - academic.oup.com
The intraclass correlation coefficient (ICC) and the concordance correlation coefficient (CCC)
are two of the most popular measures of agreement for variables measured on a …
are two of the most popular measures of agreement for variables measured on a …
An errors-in-variables model based on the Birnbaum–Saunders distribution and its diagnostics with an application to earthquake data
… Errors-in-variables modelling has been addressed using parametric distributions such as
the beta and simplex laws; see Carrasco et al. (2014) and Carrasco and Reid (2019). A …
the beta and simplex laws; see Carrasco et al. (2014) and Carrasco and Reid (2019). A …
Origins of phase contrast in the atomic force microscope in liquids
We study the physical origins of phase contrast in dynamic atomic force microscopy (dAFM)
in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of …
in liquids where low-stiffness microcantilever probes are often used for nanoscale imaging of …
Left behind?: male clients of female sex workers in Zambia
MA Carrasco, JG Rosen, R Phelps - AIDS care, 2020 - Taylor & Francis
Male clients of female sex workers (CFSWs) are a key-affected group within the HIV epidemic.
However, few studies have quantified HIV/STI burdens among CFSWs. This study used …
However, few studies have quantified HIV/STI burdens among CFSWs. This study used …
Pharmacologic treatment of repetitive behaviors in autism spectrum disorders: evidence of publication bias
OBJECTIVE: The goal of this study was to examine the efficacy of serotonin receptor
inhibitors (SRIs) for the treatment of repetitive behaviors in autism spectrum disorders (ASD). …
inhibitors (SRIs) for the treatment of repetitive behaviors in autism spectrum disorders (ASD). …