Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems
…, AJ Salisbury, JS Revanna, KD Bunner… - Nucleic acids …, 2020 - academic.oup.com
Genomic enhancer elements regulate gene expression programs important for neuronal fate
and function and are implicated in brain disease states. Enhancers undergo bidirectional …
and function and are implicated in brain disease states. Enhancers undergo bidirectional …
[HTML][HTML] Corticostriatal dysfunction in Huntington's disease: the basics
KD Bunner, GV Rebec - Frontiers in human neuroscience, 2016 - frontiersin.org
The main input to the basal ganglia, the corticostriatal pathway, shows some of the earliest
signs of neuropathology in Huntington’s disease (HD), an inherited neurodegenerative …
signs of neuropathology in Huntington’s disease (HD), an inherited neurodegenerative …
Amphetamine elevates nucleus accumbens dopamine via an action potential‐dependent mechanism that is modulated by endocannabinoids
DP Covey, KD Bunner, DR Schuweiler… - European Journal of …, 2016 - Wiley Online Library
The reinforcing effects of abused drugs are mediated by their ability to elevate nucleus
accumbens dopamine. Amphetamine ( AMPH ) was historically thought to increase dopamine by …
accumbens dopamine. Amphetamine ( AMPH ) was historically thought to increase dopamine by …
Up‐regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease
BR Miller, JL Dorner, KD Bunner… - Journal of …, 2012 - Wiley Online Library
J. Neurochem. (2012) 121, 629–638. Abstract A corticostriatal‐dependent deficit in the
release of ascorbate (AA), an antioxidant vitamin and neuromodulator, occurs concurrently in …
release of ascorbate (AA), an antioxidant vitamin and neuromodulator, occurs concurrently in …
Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats
…, C Rangel‐Barajas, V Iyer, KD Bunner… - Addiction …, 2022 - Wiley Online Library
Glutamate signalling through the N‐methyl‐d‐aspartate receptor (NMDAR) activates the
enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (…
enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (…
[HTML][HTML] Striatal network modeling in Huntington's Disease
A Ponzi, SJ Barton, KD Bunner… - PLoS computational …, 2020 - journals.plos.org
Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs
display coherent burst firing cell assembly activity patterns, even though isolated MSNs do not …
display coherent burst firing cell assembly activity patterns, even though isolated MSNs do not …
Measuring movement in health and disease
GV Rebec, DM Koceja, KD Bunner - Brain Research Bulletin, 2022 - Elsevier
Evaluating and quantifying the many aspects of movement – from open-field locomotion and
stepping patterns in rodent models to stride trajectory and postural sway in human patients …
stepping patterns in rodent models to stride trajectory and postural sway in human patients …
Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcription
…, RC Simon, AJ Salisbury, JS Revanna, KD Bunner… - bioRxiv, 2018 - biorxiv.org
Distal enhancer elements in DNA enable higher-order chromatin interactions that facilitate
gene expression programs and thus contribute to cellular phenotype and function. In the brain…
gene expression programs and thus contribute to cellular phenotype and function. In the brain…
Voltammetry in behaving animals
KD Bunner, GV Rebec - Receptor and Ion Channel Detection in the Brain …, 2016 - Springer
Fast-scan cyclic voltammetry (FSCV) is an electrochemical technique that provides rapid
and reliable detection of key brain neurotransmitters (eg, dopamine and other monoamines) …
and reliable detection of key brain neurotransmitters (eg, dopamine and other monoamines) …
Huntington's disease and dementia: from transgenic models to molecular neuropathology
AM Estrada-Sánchez, KD Bunner, GV Rebec - Diet and Nutrition in …, 2015 - Elsevier
Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by
progressive development of involuntary movements, psychiatric disturbances, and loss of …
progressive development of involuntary movements, psychiatric disturbances, and loss of …