Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems

…, AJ Salisbury, JS Revanna, KD Bunner… - Nucleic acids …, 2020 - academic.oup.com
Genomic enhancer elements regulate gene expression programs important for neuronal fate
and function and are implicated in brain disease states. Enhancers undergo bidirectional …

[HTML][HTML] Corticostriatal dysfunction in Huntington's disease: the basics

KD Bunner, GV Rebec - Frontiers in human neuroscience, 2016 - frontiersin.org
The main input to the basal ganglia, the corticostriatal pathway, shows some of the earliest
signs of neuropathology in Huntington’s disease (HD), an inherited neurodegenerative …

Amphetamine elevates nucleus accumbens dopamine via an action potential‐dependent mechanism that is modulated by endocannabinoids

DP Covey, KD Bunner, DR Schuweiler… - European Journal of …, 2016 - Wiley Online Library
The reinforcing effects of abused drugs are mediated by their ability to elevate nucleus
accumbens dopamine. Amphetamine ( AMPH ) was historically thought to increase dopamine by …

Up‐regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington's disease

BR Miller, JL Dorner, KD Bunner… - Journal of …, 2012 - Wiley Online Library
J. Neurochem. (2012) 121, 629–638. Abstract A corticostriatal‐dependent deficit in the
release of ascorbate (AA), an antioxidant vitamin and neuromodulator, occurs concurrently in …

Inhibition of PSD95‐nNOS protein–protein interactions decreases morphine reward and relapse vulnerability in rats

…, C Rangel‐Barajas, V Iyer, KD Bunner… - Addiction …, 2022 - Wiley Online Library
Glutamate signalling through the N‐methyl‐d‐aspartate receptor (NMDAR) activates the
enzyme neuronal nitric oxide synthase (nNOS) to produce the signalling molecule nitric oxide (…

[HTML][HTML] Striatal network modeling in Huntington's Disease

A Ponzi, SJ Barton, KD Bunner… - PLoS computational …, 2020 - journals.plos.org
Medium spiny neurons (MSNs) comprise over 90% of cells in the striatum. In vivo MSNs
display coherent burst firing cell assembly activity patterns, even though isolated MSNs do not …

Measuring movement in health and disease

GV Rebec, DM Koceja, KD Bunner - Brain Research Bulletin, 2022 - Elsevier
Evaluating and quantifying the many aspects of movement – from open-field locomotion and
stepping patterns in rodent models to stride trajectory and postural sway in human patients …

Enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcription

…, RC Simon, AJ Salisbury, JS Revanna, KD Bunner… - bioRxiv, 2018 - biorxiv.org
Distal enhancer elements in DNA enable higher-order chromatin interactions that facilitate
gene expression programs and thus contribute to cellular phenotype and function. In the brain…

Voltammetry in behaving animals

KD Bunner, GV Rebec - Receptor and Ion Channel Detection in the Brain …, 2016 - Springer
Fast-scan cyclic voltammetry (FSCV) is an electrochemical technique that provides rapid
and reliable detection of key brain neurotransmitters (eg, dopamine and other monoamines) …

Huntington's disease and dementia: from transgenic models to molecular neuropathology

AM Estrada-Sánchez, KD Bunner, GV Rebec - Diet and Nutrition in …, 2015 - Elsevier
Huntington’s disease (HD) is an inherited neurodegenerative disorder characterized by
progressive development of involuntary movements, psychiatric disturbances, and loss of …