Amyotrophic lateral sclerosis (ALS), a fatal disease causing progressive loss of motor neurons,
still has no effective treatment. We developed a phenotypic screen to repurpose existing …

Ubiquitination is an important posttranslational modification that regulates various cellular
processes, including signal transduction. However, physiological roles of ubiquitination in the …

Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disorder that is characterized
by the selective death of motor neurons. While the fundamental cause of the disorder is …

Zinc is an essential trace element, and impaired zinc homeostasis is implicated in the
pathogenesis of various human diseases. However, the mechanisms cells use to respond to zinc …

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by the selective loss of upper and lower motoneurons. Although >100 different …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no cure. To
develop effective treatments for this devastating disease, an appropriate strategy for targeting …

The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER
stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder. Despite its
severity, there are no effective treatments because of the complexity of its pathogenesis. As …

Mutant genes that underlie Mendelian forms of amyotrophic lateral sclerosis (ALS) and
biochemical investigations of genetic disease models point to potential driver pathophysiological …

It is widely accepted that enhanced uterine inflammation associated with microbial infection
is a main causative factor for preterm birth. However, little is known about the molecular …