Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of
oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to …

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a
crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM …

Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions
are a major cause of post-operative and dialysis-related complications, yet their patho-…

Although small-molecule drug discovery efforts have focused largely on enzyme, receptor,
and ion-channel targets, there has been an increase in such activities to search for protein-…

Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death.
Underlying biological processes involve induced massive deposition of extracellular matrix (…

The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been
shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different …

Highlights • Complex phenotypic imaging assays aim at mimicking the biology of interest. •
Cellular profiling in high-content assays improve description of compound actions. • …

Totipotent cells hold enormous potential for regenerative medicine. Thus, the development
of cellular models recapitulating totipotent-like features is of paramount importance. Cells …

The ubiquitin (Ub)-related modifier Urm1 functions as a sulfur carrier in tRNA thiolation by
means of a mechanism that requires the formation of a thiocarboxylate at the C-terminal …

The COVID-19 pandemic caused by SARS-CoV-2 has been socially and economically
devastating. Despite an unprecedented research effort and available vaccines, effective …