User profiles for Kenneth D. Poss
Kenneth PossDuke University Verified email at duke.edu Cited by 24613 |
Heart regeneration in zebrafish
KD Poss, LG Wilson, MT Keating - Science, 2002 - science.org
Cardiac injury in mammals and amphibians typically leads to scarring, with minimal
regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate …
regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate …
The zebrafish as a model for complex tissue regeneration
M Gemberling, TJ Bailey, DR Hyde, KD Poss - Trends in genetics, 2013 - cell.com
For centuries, philosophers and scientists have been fascinated by the principles and
implications of regeneration in lower vertebrate species. Two features have made zebrafish an …
implications of regeneration in lower vertebrate species. Two features have made zebrafish an …
Tales of regeneration in zebrafish
KD Poss, MT Keating… - … dynamics: an official …, 2003 - Wiley Online Library
Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …
Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes
Recent studies indicate that mammals, including humans, maintain some capacity to renew
cardiomyocytes throughout postnatal life 1 , 2 . Yet, there is little or no significant cardiac …
cardiomyocytes throughout postnatal life 1 , 2 . Yet, there is little or no significant cardiac …
[HTML][HTML] A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration
…, JE Holdway, RW Roberts, CG Burns, KD Poss - Cell, 2006 - cell.com
Zebrafish possess a unique yet poorly understood capacity for cardiac regeneration. Here,
we show that regeneration proceeds through two coordinated stages following resection of …
we show that regeneration proceeds through two coordinated stages following resection of …
Reduced stress defense in heme oxygenase 1-deficient cells
KD Poss, S Tonegawa - Proceedings of the National …, 1997 - National Acad Sciences
Stressed mammalian cells up-regulate heme oxygenase 1 (Hmox1; EC 1.14.99.3 ), which
catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of …
catabolizes heme to biliverdin, carbon monoxide, and free iron. To assess the potential role of …
Heme oxygenase 1 is required for mammalian iron reutilization
KD Poss, S Tonegawa - Proceedings of the National …, 1997 - National Acad Sciences
The majority of iron for essential mammalian biological activities such as erythropoiesis is
thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking …
thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking …
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
The zebrafish is firmly established as a genetic model for the study of vertebrate blood
development. Here we have characterized the blood-forming system of adult zebrafish. Each …
development. Here we have characterized the blood-forming system of adult zebrafish. Each …
Haem oxygenase-1 prevents cell death by regulating cellular iron
…, H Wolosker, DE Barañano, S Doré, KD Poss… - Nature cell …, 1999 - nature.com
Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here
we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, …
we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, …
[PDF][PDF] Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration
…, RJ Major, N Blum, RD Dahn, G Begemann, KD Poss - Developmental cell, 2011 - cell.com
Zebrafish heart regeneration occurs through the activation of cardiomyocyte proliferation in
areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium …
areas of trauma. Here, we show that within 3 hr of ventricular injury, the entire endocardium …