Toward development of a precision medicine framework for metastatic, castration-resistant
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …

One hundred consecutive patients with acute pancreatitis have been evaluated. Fifteen
patients died and 16 were seriously ill requiring over one week of intensive care. Pancreatitis …

Seventeen staged, bilateral total hip arthroplasties performed in 17 patients were reviewed
to compare side-to-side polyethylene wear. Implants used on both sides were similar except …

Classical Hodgkin lymphoma (cHL) is characterized by sparsely distributed Hodgkin and
Reed-Sternberg (HRS) cells amid reactive host background, complicating the acquisition of …

Importance Understanding molecular mechanisms of response and resistance to anticancer
therapies requires prospective patient follow-up and clinical and functional validation of …

von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and
megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor …

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence
leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (…

Background Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate
cancer that may arise de novo or in patients previously treated with hormonal therapies for …

One hundred consecutive, primary simultaneous bilateral total knee arthroplasties were
prospectively compared with 100 consecutive, primary unilateral total knee arthroplasties in …