A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping
fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and …

Neoadjuvant chemotherapy (NAC) prior to surgery and immune checkpoint therapy (ICT) have
revolutionized bladder cancer management. However, stratification of patients that would …

Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the
brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell (DTC…

Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast
cancer subtype typified by the presence of p53 mutations (∼80%), elevated immune gene …

Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) is one of the most
sensitive, economical and widely used methods for evaluating gene expression. However, …

Strategies are needed to better identify patients that will benefit from immunotherapy alone
or who may require additional therapies like chemotherapy or radiotherapy to overcome …

Bladder cancer (BLCA) is more common in men but more aggressive in women. Sex-based
differences in cancer biology are commonly studied using a murine model with BLCA …

Genetic deficiency of dystrophin leads to disability and premature death in Duchenne
muscular dystrophy, affecting the heart as well as skeletal muscle. Here we report that …

Molecular barcoding has provided means to link genotype to phenotype, to individuate cells
in single-cell analyses, to enable the tracking of evolving lineages, and to facilitate the …

Objective CCA, outward remodeling of capillaries that anastomose 2 arteriolar trees with
different parent feed arteries, may represent a therapeutic target for patients who lack collaterals…