The Genome Sequence of Drosophila melanogaster
…, RG Blazej, M Champe, BD Pfeiffer, KH Wan… - Science, 2000 - science.org
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …
and serves as a model system for the investigation of many developmental and cellular …
The developmental transcriptome of Drosophila melanogaster
…, L Langton, N Perrimon, JE Sandler, KH Wan… - Nature, 2011 - nature.com
Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless,
its genome still contains unannotated coding and non-coding genes, transcripts, exons …
its genome still contains unannotated coding and non-coding genes, transcripts, exons …
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
…, N Sher, R Spokony, D Sturgill, M van Baren, KH Wan… - Science, 2010 - science.org
To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …
Tools for neuroanatomy and neurogenetics in Drosophila
…, A Scully, JW Carlson, KH Wan… - Proceedings of the …, 2008 - National Acad Sciences
We demonstrate the feasibility of generating thousands of transgenic Drosophila melanogaster
lines in which the expression of an exogenous gene is reproducibly directed to distinct …
lines in which the expression of an exogenous gene is reproducibly directed to distinct …
[HTML][HTML] Diversity and dynamics of the Drosophila transcriptome
…, BW Booth, J Wen, S Park, AM Suzuki, KH Wan… - Nature, 2014 - nature.com
Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …
[HTML][HTML] A protein complex network of Drosophila melanogaster
…, O Cenaj, E McKillip, S Shah, M Stapleton, KH Wan… - Cell, 2011 - cell.com
Determining the composition of protein complexes is an essential step toward understanding
the cell as an integrated system. Using coaffinity purification coupled to mass spectrometry …
the cell as an integrated system. Using coaffinity purification coupled to mass spectrometry …
Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster
…, KL Schulze, H Pan, Y He, R Spokony, KH Wan… - Nature …, 2009 - nature.com
We constructed Drosophila melanogaster bacterial artificial chromosome libraries with 21-kilobase
and 83-kilobase inserts in the P[acman] system. We mapped clones representing 12-…
and 83-kilobase inserts in the P[acman] system. We mapped clones representing 12-…
The Release 6 reference sequence of the Drosophila melanogaster genome
RA Hoskins, JW Carlson, KH Wan, S Park… - Genome …, 2015 - genome.cshlp.org
Drosophila melanogaster plays an important role in molecular, genetic, and genomic studies
of heredity, development, metabolism, behavior, and human disease. The initial reference …
of heredity, development, metabolism, behavior, and human disease. The initial reference …
Sequence Finishing and Mapping of Drosophila melanogaster Heterochromatin
…, D Acevedo, M Evans-Holm, E Frise, KH Wan… - Science, 2007 - science.org
Genome sequences for most metazoans and plants are incomplete because of the presence
of repeated DNA in the heterochromatin. The heterochromatic regions of Drosophila …
of repeated DNA in the heterochromatin. The heterochromatic regions of Drosophila …
[HTML][HTML] Comparative analysis of the transcriptome across distant species
The transcriptome is the readout of the genome. Identifying common features in it across distant
species can reveal fundamental principles. To this end, the ENCODE and modENCODE …
species can reveal fundamental principles. To this end, the ENCODE and modENCODE …