Small molecules are powerful tools for investigating protein function and can serve as leads
for new therapeutics. Most human proteins, however, lack small-molecule ligands, and …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for
brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS. …

Lipids play central roles in physiology and disease, where their structural, metabolic, and
signaling functions often arise from interactions with proteins. Here, we describe a set of lipid-…

The endocannabinoids 2-arachidonoyl glycerol (2-AG) and N-arachidonoyl ethanolamine (anandamide)
are principally degraded by monoacylglycerol lipase (MAGL) and fatty acid …

Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle
to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as …

Methylation is a fundamental mechanism used in Nature to modify the structure and function
of biomolecules, including proteins, DNA, RNA, and metabolites. Methyl groups are …

In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new
olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage …

Heteroatom-rich organoboron compounds have attracted attention as modulators of enzyme
function. Driven by the unmet need to develop chemoselective access to boron chemotypes…

Phenotypic screening has identified small-molecule modulators of aging, but the mechanism
of compound action often remains opaque due to the complexities of mapping protein …