Supramolecular chemistry has recently emerged as a promising way to modulate protein
functions, but devising molecules that will interact with a protein in the desired manner is …

Acyltransferase domains control the extender unit recognition in Polyketide Synthases (PKS)
and thereby the side-chain diversity of the resulting natural products. The enzyme …

The self-organizational properties of DNA have been used to realize synthetic hosts for
protein encapsulation. However, current strategies of DNA–protein conjugation still limit true …

10.7554/eLife.05397.001 Semen is the main vector for HIV transmission and contains
amyloid fibrils that enhance viral infection. Available microbicides that target viral components …

The three-dimensional structure of a peptide is strongly influenced by its solvent environment.
In the present study, we study three cyclic tetrapeptides which serve as model peptides for …

Selective binding of the phosphate-substituted molecular tweezer 1a to protein lysine residues
was suggested to explain the inhibition of certain enzymes and the aberrant aggregation …

Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific
therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that …

Protein regions that are involved in protein–protein interactions (PPIs) very often display a
high degree of intrinsic disorder, which is reduced during the recognition process. A prime …

SMAC/DIABLO and HTRA2 are mitochondrial proteins whose amino-terminal sequences,
known as inhibitor of apoptosis binding motifs (IBMs), bind and activate ubiquitin ligases …

The polyether ionophore monensin is biosynthesized by a polyketide synthase that delivers
a mixture of monensins A and B by the incorporation of ethyl‐ or methyl‐malonyl‐CoA at its …