User profiles for Kenny L. Chan
 | Kenny L. ChanInstructor, Icahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 1123 |
[HTML][HTML] Social trauma engages lateral septum circuitry to occlude social reward
In humans, traumatic social experiences can contribute to psychiatric disorders 1 . It is suggested
that social trauma impairs brain reward function such that social behaviour is no longer …
that social trauma impairs brain reward function such that social behaviour is no longer …
[HTML][HTML] Palmitoleate reverses high fat-induced proinflammatory macrophage polarization via AMP-activated protein kinase (AMPK)
A rise in tissue-embedded macrophages displaying "M1-like" proinflammatory polarization
is a hallmark of metabolic inflammation during a high fat diet or obesity. Here we show that …
is a hallmark of metabolic inflammation during a high fat diet or obesity. Here we show that …
Central and peripheral inflammation link metabolic syndrome and major depressive disorder
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have
various negative effects on patients, their families and the public. Recent studies in humans …
various negative effects on patients, their families and the public. Recent studies in humans …
Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced alterations …
associated with systemic inflammation. Recent studies have reported stress-induced alterations …
Social stress induces autoimmune responses against the brain
Clinical studies have revealed a high comorbidity between autoimmune diseases and
psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms …
psychiatric disorders, including major depressive disorder (MDD). However, the mechanisms …
[PDF][PDF] Circulating NOD1 activators and hematopoietic NOD1 contribute to metabolic inflammation and insulin resistance
Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets
that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in …
that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in …
Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis
Obesity is associated with inflammation and immune cell recruitment to adipose tissue,
muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also …
muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also …
Individual history of winning and hierarchy landscape influence stress susceptibility in mice
Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within
social hierarchy has large effects on health and behavior. To investigate the relationship …
social hierarchy has large effects on health and behavior. To investigate the relationship …
Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release
Obesity is associated with metabolic tissue infiltration by monocyte-derived macrophages.
Saturated fatty acids contribute to proinflammatory gene induction in tissue-embedded …
Saturated fatty acids contribute to proinflammatory gene induction in tissue-embedded …