Trypanosoma brucei is a pathogenic unicellular eukaryote that infects humans and other
mammals in sub-Saharan Africa. A central feature of trypanosome biology is the single …

The flagellum of Trypanosoma brucei is a multifunctional organelle with critical roles in motility
and other aspects of the trypanosome life cycle. Trypanin is a flagellar protein required for …

Throughout morphogenesis, cells experience intracellular tensile and contractile forces on
microscopic scales. Cells also experience extracellular forces, such as static forces mediated …

During cell division, cytoplasmic organelles are not synthesized de novo, rather they are
replicated and partitioned between daughter cells. Partitioning of the vacuole in the budding …

The flagellum of African trypanosomes is an essential and multifunctional organelle that
functions in motility, cell morphogenesis, and host-parasite interaction. Previous studies of the …

African trypanosomes are devastating human and animal pathogens. Trypanosoma brucei
rhodesiense and T. b. gambiense subspecies cause the fatal human disease known as …

In teleosts, proper balance and hearing depend on mechanical sensors in the inner ear.
These sensors include actin-based microvilli and microtubule-based cilia that extend from the …

The discovery of double-stranded RNA interference (dsRNAi) in Trypanosoma brucei provides
a convenient method to generate knockout phenotypes in this protozoan parasite [Ngo H, …

African trypanosomes are devastating human and animal pathogens that cause significant
human mortality and limit economic development in sub-Saharan Africa. Studies of …

During infection of a mammalian host, African trypanosomes are in constant contact with the
host’s immune system. These protozoan parasites are infamous for their ability to evade the …