TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is
functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and …

We and others recently reported tumor necrosis factor (TNF) and apoptosis ligand–related
leukocyte-expressed ligand 1 (TALL-1) as a novel member of the TNF ligand family that is …

Optimal T cell activation requires the interactions of co-stimulatory molecules, such as those
in the CD28 and B7 protein families. Recently, we described the co-stimulatory properties of …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. …

4‐1BB is a member of the TNF receptor family predominantly expressed on activated T cells,
and binds an inducible ligand found on B cells, macrophages and dendritic cells. Whereas …

The role of antigen‐presenting cell (APC)‐derived cytokines in T cell activation is still
controversial. Highly purified CD4 T cell populations of the naive and short‐term Th1 and Th2 …

… Khare, PhD Frances Lee, MS Kent Miner, MS Yi-Ling Hu, BS Marina Stolina, PhD Nessa
Hawkins, MS Qing Chen, PhD Shu-yin Joanne Ho, MS Hosung Min, Fei Xiong, PhD Tom …

Lymphotoxin (LT) is a cytokine that orchestrates lymphoid neogenesis and formation of
germinal center reactions. LT exists as a membrane heterotrimer of α and β subunits and is …

Structure-based rational design led to the synthesis of a novel series of potent PI3K inhibitors.
The optimized pyrrolopyridine analogue 63 was a potent and selective PI3Kβ/δ dual …

Many studies have classified CD4 responses into either Th1-like or Th2-like, based on
cytokine secretion profiles, but little significance has been placed on Th0 cells. This has largely …