Organogenesis is a complex and interconnected process that is orchestrated by multiple
boundary tissue interactions 1 , 2 , 3 , 4 , 5 , 6 – 7 . However, it remains unclear how individual, …

Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut
through a series of inductive interactions between the definitive endoderm (DE) and the …

Genotype-phenotype associations for common diseases are often compounded by pleiotropy
and metabolic state. Here, we devised a pooled human organoid-panel of steatohepatitis …

Abstract Development of visceral organs such as the esophagus, lung, liver and stomach
are coordinated by reciprocal signaling interactions between the endoderm and adjacent …

We analysed the faecal microbiota of 27 Japanese patients with paediatric-onset PSC as
well as 16 age-matched patients with UC and 23 healthy controls (HCs)(see online …

Human organoids are emerging as a valuable resource to investigate human organ development
and disease. The applicability of human organoids has been limited, partly due to the …

Primary sclerosing cholangitis (PSC) is a liver disease known for its frequent concurrence
with inflammatory bowel disease. Dysbiosis of the gut microbiota in PSC was reported in …

The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates
significant interindividual variability. In addition to showing more disease in males, the …

β-catenin is a multifunctional protein that plays crucial roles in embryonic development,
physiological homeostasis, and a wide variety of human cancers. Previously, we showed that in …

Background Perturbagen analysis of Crohn’s disease (CD) ileal gene expression data identified
small molecules including eicosatetraynoic acid (ETYA), which may exert an antifibrotic …