Background & Aim Patients with inflammatory bowel diseases (IBD), specifically those
treated with anti–tumor necrosis factor (TNF)α biologics, are at high risk for vaccine-preventable …

Objective Although anti-tumour necrosis factor alpha (anti-TNFα) therapies represent a major
breakthrough in IBD therapy, their cost–benefit ratio is hampered by an overall 30% non-…

10.7554/eLife.40553.001 To identify factors that regulate gut microbiota density and the impact
of varied microbiota density on health, we assayed this fundamental ecosystem property …

Background & Aims Pouchitis that develops in patients with ulcerative colitis after total
proctocolectomy and ileal pouch anal anastomosis is usually treated with antibiotics. Some …

BACKGROUND & AIMS: Interactions between lymphocytes and intestinal epithelial cells
occur in the subepithelial space of the gastrointestinal tract. Normal human lamina propria …

The Mediterranean diet (MED) is associated with the modification of gut microbial
composition. In this pilot study, we investigate the feasibility of a microbiota-targeted MED-based …

Crohn's disease (CD), ulcerative colitis (UC), and pouchitis are multifactorial and chronic
inflammatory bowel diseases (IBD). Pouchitis develops in former UC patients after …

Background Intestinal epithelial cells (IECs) are the first to encounter luminal microorganisms
and actively participate in intestinal immunity. We reported that IECs express the β-glucan …

Background and Aims Bacterial urease is a major virulence factor of human pathogens, and
murine models have shown that it can contribute to the pathogenesis of inflammatory bowel …

Background & Aims The early stages of Crohn's disease (CD) course are heterogeneous,
and it is a challenge to predict the course of disease in patients with new diagnosis. Methods …