FAN1, a DNA structure-specific nuclease, interacts with MLH1, but the repair pathways in
which this complex acts are unknown. FAN1 processes DNA interstrand crosslinks (ICLs) and …

RAS mutations are the most common oncogenic drivers across human cancers, but there
remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable …

… Fishwick, Keri Marie (2020) Isolation of SOS2 inhibiting Affimer reagents to study the role
of SOS2 in Ras mediated cancer signalling. MSc by research thesis, University of Leeds …

1. Abstract In the mammalian embryo, specification of the anteroposterior (AP) axis demarcates
one of the first steps of body plan formation. While this process requires interactions with …

The 1993 Winter Simulation Conference is the twenty-fifth annual conference in the series.
This particular edition of the conference is noteable for its size, with ten tracks (simultaneous …

The Road to Pfailure..... so....; many of us recognize this trek all too well. This walk is sometimes
an elated one, sometimes a dejected one, but always, when is all is said and done, one …

It is evident from the literature that the concept of strategy has been adopted from the military
and well modified for use in the business world. However, despite the thousands years old …

… Often the consumer is not Bond, as much as other men of ethnically inferior race, (for example,
Darko Kerim in From Russia with Love). Nevertheless, Black notes that changing social …

Because protein-protein interactions underpin most biological processes, developing tools
that target them to understand their function or to inform the development of therapeutics is an …

The first cinematic appearance of British secret agent James Bond in the initial entry of his
film series, Dr. No (1962), occurs at a posh London casino where a beautiful woman in a red …