… Author links open overlay panel Kerry R Love , Neil C Dalvie , J Christopher Love … The
authors would like to acknowledge Joseph R. Brady and Ang A. Tu for conversation on …

Conventional manufacturing of protein biopharmaceuticals in centralized, large-scale, single-product
facilities is not well-suited to the agile production of drugs for small patient …

Background Pichia pastoris has emerged as an important alternative host for producing
recombinant biopharmaceuticals, owing to its high cultivation density, low host cell protein …

Pichia pastoris is widely used as a host for recombinant protein production. More than 500
proteins have been expressed in the organism at a variety of cultivation scales, from small …

Global containment of COVID-19 still requires accessible and affordable vaccines for low-
and middle-income countries (LMICs). Recently approved vaccines provide needed …

There is growing interest in the use of nonmodel microorganisms as hosts for biopharmaceutical
manufacturing. These hosts require genomic engineering to meet clinically relevant …

The real-time observation of protein dynamics in living cells and organisms is of fundamental
importance for understanding biological processes. Most approaches to labeling proteins …

Global containment of COVID-19 still requires accessible and affordable vaccines for low-and
middle-income countries (LMICs). 1 Recently approved vaccines provide needed …

The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to modulate
function and is a key step in protein degradation, epigenetic modification and intracellular …

In this study, we describe a new approach for the characterization of process‐related impurities
along with an in silico tool to generate orthogonal, integrated downstream purification …