Cohesin complexes mediate sister-chromatid cohesion in dividing cells but may also contribute
to gene regulation in postmitotic cells. How cohesin regulates gene expression is not …

Recent studies of genome-wide chromatin interactions have revealed that the human genome
is partitioned into many self-associating topological domains. The boundary sequences …

The eukaryotic genome is organized within cells as chromatin. For proper information output,
higher-order chromatin structures can be regulated dynamically. How such structures form …

Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion
by connecting replicated DNA molecules. Cohesin also has important roles in gene …

Chromosome conformation capture (3C) technology is a powerful and increasingly popular
tool for analyzing the spatial organization of genomes. Several 3C variants have been …

The cohesin complex is crucial for chromosome segregation during mitosis and has recently
also been implicated in transcriptional regulation and chromatin architecture. The NIPBL …

Mammalian chromosomes are three-dimensional entities shaped by converging and opposing
forces. Mitotic cell division induces marked chromosome condensation, but following …

Cohesin is a DNA-binding protein complex that is essential for sister chromatid cohesion
and facilitates the repair of damaged DNA. In addition, cohesin has important roles in …

Cornelia de Lange syndrome ( CdLS ) and KBG syndrome are two distinct developmental
pathologies sharing common features such as intellectual disability, psychomotor delay, and …

Background Significant efforts have recently been put into the investigation of the spatial
organization and the chromatin-interaction networks of genomes. Chromosome conformation …