Candida albicans cells with increased cell wall chitin have reduced echinocandin susceptibility
in vitro. The aim of this study was to investigate whether C. albicans cells with elevated …

Candida albicans is a human opportunist pathogen that can grow as yeast, pseudohyphae,
or true hyphae in vitro and in vivo, depending on environmental conditions. Reversible …

The fungal cell wall confers cell morphology and protection against environmental insults. For
fungal pathogens, the cell wall is a key immunological modulator and an ideal therapeutic …

ABSTRACT Treatment of Aspergillus fumigatus with echinocandins such as caspofungin
inhibits the synthesis of cell wall β-1,3-glucan, which triggers a compensatory stimulation of …

Cryptococcus neoformans is a human fungal pathogen that often causes infections in
immunocompromised individuals. Upon inhalation into the lungs C. neoformans differentiates into …

Most fungal pathogens of humans display robust protective oxidative stress responses that
contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen …

… Author links open overlay panel Keunsook K. Lee a , Karen Kubo b c , Jehan Abdelmoneim
Abdelaziz a , Iain Cunningham a , Alessandra de Silva Dantas a , Xiaolin Chen b , Hiroki …

The unfolded protein response (UPR), crucial for the maintenance of endoplasmic reticulum
(ER) homeostasis, is tied to the regulation of multiple cellular processes in pathogenic fungi. …

Four Candida spp. (albicans, glabrata, tropicalis, parapsilosis) cause >95% of invasive
Candida infections. C. albicans elicits immune responses via pathogen recognition receptors …

The advent of the genomic era has made elucidating gene function on a large scale a pressing
challenge. ORFeome collections, whereby almost all ORFs of a given species are cloned …