Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

Long-term epigenetic reprogramming of innate immune cells in response to microbes, also
termed "trained immunity," causes prolonged altered cellular functionality to protect from …

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …

COVID-19-induced "acute respiratory distress syndrome" (ARDS) is associated with prolonged
respiratory failure and high mortality, but the mechanistic basis of lung injury remains …

Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are
used clinically, eg, to induce immunity against cancer. However, their physiological …

Extravasation of monocytes into tissue and to the site of injury is a fundamental immunological
process, which requires rapid responses via post translational modifications (PTM) of …

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

Differentiation of inflammatory macrophages from monocytes is characterized by an orderly
integration of epigenetic and transcriptional regulatory mechanisms guided by lineage-…