… c, TCF reporter assays of human AXIN2 in 293 cells. All reporter assays performed in
triplicate are shown. The induction of the TCF-dependent transcription was consistently higher in …

Purpose : We determine the relative sensitivities of cytology and fluorescence in situ hybridization
(FISH) for the detection of urothelial carcinoma. Materials and Methods : A mixture of …

To date, at least four genes involved in DNA mismatch repair (MMR) have been demonstrated
to be altered in the germline of patients with hereditary nonpolyposis colon cancer: hMSH2…

There is limited information on test performance for detecting cholangiocarcinoma in primary
sclerosing cholangitis (PSC), particularly when used sequentially. This study aimed to …

A comprehensive analysis of somatic and germline mutations related to DNA mismatch–repair
(MMR) genes can clarify the prevalence and mechanism of inactivation in colorectal …

METHODS: Bile duct brushing and aspirate specimens were collected from 131 patients being
evaluated for possible malignant bile duct strictures. Both specimen types were assessed …

The purpose of this study was to develop a multitarget, multicolor fluorescence in situ
hybridization (FISH) assay for the detection of urothelial carcinoma (UC) in urine specimens. …

Patients with cholangiocarcinoma often present with locally advanced or metastatic disease.
There is a need for effective therapeutic strategies for advanced stage cholangiocarcinoma. …

Background & Aims: Two advanced cytologic techniques for detecting aneuploidy—digital
image analysis (DIA) and fluorescence in situ hybridization (FISH)—have recently been …

BACKGROUND: Microsatellite instability (MSI) and allelic imbalance involving chromosome
arms 5q, 8p, 17p, and 18q are genetic alterations commonly found in colorectal cancer. We …