User profiles for Kevin CJ Nixon
 | Kevin CJ NixonPrincess Margaret Cancer Centre, UHN Verified email at uhn.ca Cited by 181 |
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
…, R Krishnan, JJ Reynolds, KCJ Nixon… - Nucleic Acids …, 2023 - academic.oup.com
BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-mutant
tumors are high-grade, recurrent, and often become resistant to standard therapies. …
tumors are high-grade, recurrent, and often become resistant to standard therapies. …
RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells
…, M Lapierre, B Gautreau, KCJ Nixon… - Nucleic Acids …, 2023 - academic.oup.com
Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies,
including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant …
including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant …
[PDF][PDF] A syndromic neurodevelopmental disorder caused by mutations in SMARCD1, a core SWI/SNF subunit needed for context-dependent neuronal gene regulation …
KCJ Nixon, J Rousseau, MH Stone, M Sarikahya… - The American Journal of …, 2019 - cell.com
Mutations in several genes encoding components of the SWI/SNF chromatin remodeling
complex cause neurodevelopmental disorders (NDDs). Here, we report on five individuals with …
complex cause neurodevelopmental disorders (NDDs). Here, we report on five individuals with …
Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy
SMK Farhan, KCJ Nixon, M Everest… - Human molecular …, 2017 - academic.oup.com
Defects in neuronal migration cause brain malformations, which are associated with
intellectual disability (ID) and epilepsy. Using exome sequencing, we identified compound …
intellectual disability (ID) and epilepsy. Using exome sequencing, we identified compound …
Mushroom body specific transcriptome analysis reveals dynamic regulation of learning and memory genes after acquisition of long-term courtship memory in …
SG Jones, KCJ Nixon, MC Chubak… - G3: Genes, Genomes …, 2018 - academic.oup.com
The formation and recall of long-term memory (LTM) requires neuron activity-induced gene
expression. Transcriptome analysis has been used to identify genes that have altered …
expression. Transcriptome analysis has been used to identify genes that have altered …
Targeting the ubiquitin–proteasome system using the UBA1 inhibitor TAK-243 is a potential therapeutic strategy for small-cell lung cancer
Purpose: Small cell lung cancer (SCLC) is an aggressive disease with an overall 5-year
survival rate of less than 10%. Treatment for SCLC with cisplatin/etoposide chemotherapy (C/E) …
survival rate of less than 10%. Treatment for SCLC with cisplatin/etoposide chemotherapy (C/E) …
[HTML][HTML] Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies
…, B Davidson, C Karamboulas, KCJ Nixon… - Cancers, 2022 - mdpi.com
Simple Summary 6-O-endosulfatases, SULF1 and SULF2, are oncogenic in multiple
malignancies and are associated with poor survival outcomes. SULF1 is one of the most …
malignancies and are associated with poor survival outcomes. SULF1 is one of the most …
Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body
MC Chubak, KCJ Nixon, MH Stone… - Disease Models & …, 2019 - journals.biologists.com
Technology has led to rapid progress in the identification of genes involved in neurodevelopmental
disorders such as intellectual disability (ID), but our functional understanding of the …
disorders such as intellectual disability (ID), but our functional understanding of the …
Proteinase-activated receptor 4 activation triggers cell membrane blebbing through RhoA and β-arrestin
CMG Vanderboor, PE Thibeault, KCJ Nixon… - Molecular …, 2020 - ASPET
Proteinase-activated receptors (PARs) are a four-member family of G-protein–coupled
receptors that are activated via proteolysis. PAR4 is a member of this family that is cleaved and …
receptors that are activated via proteolysis. PAR4 is a member of this family that is cleaved and …
Identification of SMARCD1 as a syndromic intellectual disability gene that is required for memory and context-dependent regulation of neuronal genes in Drosophila
KCJ Nixon, J Rousseau, MH Stone, M Sarikahya… - BioRxiv, 2018 - biorxiv.org
Mutations in several genes encoding components of the SWI/SNF chromatin remodeling
complex cause syndromic intellectual disability (ID). Here, we report on 5 individuals with …
complex cause syndromic intellectual disability (ID). Here, we report on 5 individuals with …