In both physiological and cell culture systems, EGF-stimulated ERK activity occurs in discrete
pulses within individual cells. Many feedback loops are present in the EGF receptor (EGFR)…

10.7554/eLife.27293.001 Cells use multiple feedback controls to regulate metabolism in
response to nutrient and signaling inputs. However, feedback creates the potential for unstable …

Centromere repeats are found in most eukaryotes and play a critical role in kinetochore
formation. Though centromere repeats exhibit considerable diversity both within and among …

OBJECTIVE The aim of this study was to screen in vitro-fertilized embryos for aneuploidies
via analysis of cfDNA in ESM samples using the Embgenix™ ESM Screen Kit to assess …

Short Abstract—To support the prediction of cell regulatory actions through to new protein
expression and fate, we characterize dynamic response models of transcription factor …

Defects in cell-to-cell signaling pathways can result in developmental abnormalities as well
as cancer. The Ras/MAPK pathway is a central regulator of gene expression, cellular …

To characterize key cell signaling pathways in cancer, we employ a modular strategy to
examine how signals propagate between two members in a pathway, using paired time series …

Receptor tyrosine kinases transduce signals through ERK and drive distinct cellular behaviors,
but it is not clear how dynamic patterns of ERK activity are generated. To approach this …

Short Abstract—Many genes are controlled by the activity of the ERK/MAPK pathway. Single-cell
methods reveal that different ERK targets are expressed at divergent levels within the …

Background Centromeres are essential for chromosome segregation, yet their DNA sequences
evolve rapidly. In most animals and plants that have been studied, centromeres contain …