The generation of pluripotent stem cells from an individual patient would enable the large-scale
production of the cell types affected by that patient's disease. These cells could in turn be …

We have explored the use of embryonic stem cells as an alternative to oocytes for reprogramming
human somatic nuclei. Human embryonic stem (hES) cells were fused with human …

Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an
attractive source for regenerative therapies. This expansion potential has been linked with the …

Defined transcription factors can induce epigenetic reprogramming of adult mammalian
cells into induced pluripotent stem cells. Although DNA factors are integrated during some …

Human pluripotent stem cells are a powerful tool for modeling brain development and disease.
The human cortex is composed of two major neuronal populations: projection neurons …

The developmental potential of human pluripotent stem cells suggests that they can produce
disease-relevant cell types for biomedical research. However, substantial variation has …

The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …

Egg and sperm cells (gametes) of the mouse are derived from a founder population of
primordial germ cells that are set aside early in embryogenesis. Primordial germ cells arise from …

Here we report an in vitro model system for studying the molecular and cellular mechanisms
that underlie the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Embryonic …

Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with
at most a few percent of manipulated embryos resulting in live births. Many of those that …