Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

…, LG Baum, J Bakkers, KH Mayo… - Proceedings of the …, 2006 - National Acad Sciences
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and
that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells …

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

…, MA Kowalska, AJ Kungl, TM Hackeng, KH Mayo… - Nature medicine, 2009 - nature.com
Atherosclerosis is characterized by chronic inflammation of the arterial wall due to
chemokine-driven mononuclear cell recruitment 1 , 2 , 3 , 4 . Activated platelets can synergize with …

Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization

…, H Heun, E McNiel, AW Griffioen, KH Mayo… - Clinical Cancer …, 2007 - AACR
Purpose: To test whether a direct antiangiogenic peptide (anginex) and a vascular endothelial
growth factor antibody (bevacizumab, Avastin) can transiently normalize vasculature …

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

…, BMM Zwaans, FCS Ramaekers, KH Mayo… - Blood, 2006 - ashpublications.org
Crucial to designing angiostatic and vascular targeting agents is the identification of target
molecules. Because angiogenesis is not limited to pathologic conditions, careful evaluation of …

Anti‐angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte‐endothelium interactions and infiltration in tumors

…, RPM Dings, L Kwee, KH Mayo… - The FASEB …, 2006 - Wiley Online Library
Tumor escape from immunity, as well as the failure of several anti‐cancer vaccination and
cellular immunotherapy approaches, is suggested to be due to the angiogenesis‐mediated …

Motional model analyses of protein and peptide dynamics using 13C and 15N NMR relaxation

VA Daragan, KH Mayo - Progress in Nuclear Magnetic Resonance …, 1997 - Elsevier
With the development of higher field magnets, more powerful and faster computers, and
improved radio frequency electronics and probe designs, NMR spectroscopy has undergone a …

[HTML][HTML] Chemokines from a structural perspective

MC Miller, KH Mayo - International journal of molecular sciences, 2017 - mdpi.com
Chemokines are a family of small, highly conserved cytokines that mediate various biological
processes, including chemotaxis, hematopoiesis, and angiogenesis, and that function by …

Anginex, a designed peptide that inhibits angiogenesis

…, HAJS BOUDIER, HFP HILLEN, KH MAYO - Biochemical …, 2001 - portlandpress.com
Novel β-sheet-forming peptide 33-mers, βpep peptides, have been designed by using a
combination approach employing basic folding principles and incorporating short sequences …

Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications

…, E Viré, RPM Dings, NTH Hoebers, KH Mayo… - Cancer research, 2006 - AACR
Tumors can escape from immunity by repressing leukocyte adhesion molecule expression
on tumor endothelial cells and by rendering endothelial cells unresponsive to inflammatory …

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

…, JWM Heemskerk, RR Koenen, KH Mayo… - Science translational …, 2017 - science.org
Chemokines orchestrate leukocyte trafficking and function in health and disease. Heterophilic
interactions between chemokines in a given microenvironment may amplify, inhibit, or …