[HTML][HTML] Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

FP Williams, K Haubrich, C Perez-Borrajero… - Biological …, 2019 - degruyter.com
TRIM proteins constitute a large, diverse and ancient protein family which play a key role in
processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour …

RNA binding regulates TRIM25-mediated RIG-I ubiquitination

K Haubrich - 2021 - archiv.ub.uni-heidelberg.de
TRIM25 is an E3 ligase of the tripartite motif protein family, that is best known for its function
in innate immunity, where it activates the pattern recognition receptor RIG-I. More recently, it …

[HTML][HTML] Breaking free from the crystal lattice: Structural biology in solution to study protein degraders

K Haubrich, VA Spiteri, W Farnaby, F Sobott… - Current Opinion in …, 2023 - Elsevier
Structural biology offers a versatile arsenal of techniques and methods to investigate the
structure and conformational dynamics of proteins and their assemblies. The growing field of …

[HTML][HTML] Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

…, M Lethier, AG van der Veen, K Haubrich… - Nature …, 2018 - nature.com
RIG-I is a viral RNA sensor that induces the production of type I interferon (IFN) in response
to infection with a variety of viruses. Modification of RIG-I with K63-linked poly-ubiquitin …

Vault RNA1–1 riboregulates the autophagic function of p62 by binding to lysine 7 and arginine 21, both of which are critical for p62 oligomerization

M Büscher, R Horos, I Huppertz, K Haubrich, N Dobrev… - RNA, 2022 - rnajournal.cshlp.org
Cellular processes can be regulated at multiple levels, including transcriptional, post-transcriptional,
and post-translational mechanisms. We have recently shown that the small, …

[HTML][HTML] Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

S Ramachandran, N Makukhin, K Haubrich… - Nature …, 2023 - nature.com
The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational
modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting …

Validation and classification of RNA binding proteins identified by mRNA interactome capture

L Dimitrova-Paternoga, K Haubrich, M Sun, A Ephrussi… - Rna, 2021 - rnajournal.cshlp.org
RNA binding proteins (RBPs) take part in all steps of the RNA life cycle and are often essential
for cell viability. Most RBPs have a modular organization and comprise a set of canonical …

Automated determination of nuclear magnetic resonance chemical shift perturbations in ligand screening experiments: the PICASSO web server

…, A Giachetti, L Cerofolini, K Haubrich… - Journal of Chemical …, 2021 - ACS Publications
Nuclear magnetic resonance (NMR) is an effective, commonly used experimental approach
to screen small organic molecules against a protein target. A very popular method consists …

[HTML][HTML] Fe65-PTB2 dimerization mimics Fe65-APP interaction

LP Feilen, K Haubrich, P Strecker, S Probst… - Frontiers in molecular …, 2017 - frontiersin.org
Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor
protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two …

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

…, S Ramachandran, Z Rutter, S Chakraborti, K Haubrich… - bioRxiv, 2024 - biorxiv.org
The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and
lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular …