… In this work, Maximina Yun and Kevin Hiom show that CtIP, a protein recently identified as
a participant in the resection of broken DNA ends, serves to switch between these pathways. …

The RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a
double-strand break between the recombination signal sequence (RSS) and the neighboring …

The protein predicted to be defective in individuals with Fanconi anemia complementation
group J (FA-J), FANCJ, is a missing component in the Fanconi anemia pathway of genome …

Loss of the tumour suppressor BRCA1 results in profound chromosomal instability. The
fundamental defect underlying this catastrophic phenotype is not yet known. In vivo, BRCA1 …

Fanconi anemia (FA) is a heritable human cancer-susceptibility disorder, delineating a
genetically heterogenous pathway for the repair of replication-blocking lesions such as …

V (D) J recombination requires a pair of signal sequences with spacer lengths of 12 and 23
bp between the conserved heptamer and nonamer elements. The RAG1 and RAG2 proteins …

The 12/23 rule requires that V(D)J recombination only occurs between recombination signals
with 12 and 23 base pair spacers. We show that the 12/23 rule is established prior to DNA …

BRIP1 (also called BACH1) is a DEAH helicase that interacts with the BRCT domain of BRCA1
(refs. 1 – 6 ) and has an important role in BRCA1-dependent DNA repair and checkpoint …

An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is
the mono‐ubiquitination of histone H2A by the combined action of the Posterior sex combs (…

The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase
that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and …