User profiles for Kevin J Bender

Kevin J. Bender

Center for Integrative Neuroscience, Dept. of Neurology, UCSF
Verified email at ucsf.edu
Cited by 3939

Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex

VA Bender, KJ Bender, DJ Brasier… - Journal of …, 2006 - Soc Neuroscience
Many cortical synapses exhibit spike timing-dependent plasticity (STDP) in which the
precise timing of presynaptic and postsynaptic spikes induces synaptic strengthening [long-term …

Progress in understanding and treating SCN2A-mediated disorders

…, CM Taylor, J Tjernagel, JE Spiro, KJ Bender - Trends in …, 2018 - cell.com
Advances in gene discovery for neurodevelopmental disorders have identified SCN2A
dysfunction as a leading cause of infantile seizures, autism spectrum disorder, and intellectual …

[HTML][HTML] Opposing effects on NaV1. 2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures

…, KN Berrios, JY An, SJ Sanders, KJ Bender - Biological …, 2017 - Elsevier
Background Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel
Na V 1.2 are important risk factors for autism spectrum disorder (ASD), developmental delay…

[HTML][HTML] Medial amygdalar aromatase neurons regulate aggression in both sexes

EK Unger, KJ Burke, CF Yang, KJ Bender, PM Fuller… - Cell reports, 2015 - cell.com
Aromatase-expressing neuroendocrine neurons in the vertebrate male brain synthesize
estradiol from circulating testosterone. This locally produced estradiol controls neural circuits …

The physiology of the axon initial segment

KJ Bender, LO Trussell - Annual review of neuroscience, 2012 - annualreviews.org
The action potential generally begins in the axon initial segment (AIS), a principle confirmed
by 60 years of research; however, the most recent advances have shown that a very rich …

[PDF][PDF] The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex

…, KJ Burke, RL Clarkson, SJ Sanders, KJ Bender - Neuron, 2019 - cell.com
Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …

[PDF][PDF] Axon initial segment Ca2+ channels influence action potential generation and timing

KJ Bender, LO Trussell - Neuron, 2009 - cell.com
Although action potentials are typically generated in the axon initial segment (AIS), the
timing and pattern of action potentials are thought to depend on inward current originating in …

Short-and long-term plasticity at the axon initial segment

…, MN Rasband, VC Wimmer, KJ Bender - Journal of …, 2011 - Soc Neuroscience
The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of
action potential initiation and the boundary between axonal and somatodendritic …

[PDF][PDF] Social control of hypothalamus-mediated male aggression

…, KJ Burke, M Borius, S Inoue, MC Chiang, KJ Bender… - Neuron, 2017 - cell.com
How environmental and physiological signals interact to influence neural circuits underlying
developmentally programmed social interactions such as male territorial aggression is …

[HTML][HTML] The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

…, CS Asensio, VS Sohal, KW Roche, KJ Bender… - Nature …, 2018 - nature.com
CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its
role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII …