User profiles for Kevin J. Chalut

Kevin Chalut

Group Leader, Altos Labs
Verified email at altoslabs.com
Cited by 3680

Cortical cell stiffness is independent of substrate mechanics

…, B Wallmeyer, NM Kronenberg, KJ Chalut… - Nature materials, 2020 - nature.com
Cortical stiffness is an important cellular property that changes during migration, adhesion
and growth. Previous atomic force microscopy (AFM) indentation measurements of cells …

[PDF][PDF] Membrane tension gates ERK-mediated regulation of pluripotent cell fate

…, C Labouesse, PH Jones, EK Paluch, KJ Chalut - Cell stem cell, 2021 - cell.com
… In this study, Chalut and colleagues investigate how changes in cell surface mechanics drive
early differentiation in embryonic stem cells and show that preventing this change leads to …

Auxetic nuclei in embryonic stem cells exiting pluripotency

…, RJM Franklin, AJ Kabla, UF Keyser, KJ Chalut - Nature materials, 2014 - nature.com
Embryonic stem cells (ESCs) self-renew in a state of naïve pluripotency in which they are
competent to generate all somatic cells. It has been hypothesized that, before irreversibly …

Interplay between mechanics and signalling in regulating cell fate

H De Belly, EK Paluch, KJ Chalut - Nature Reviews Molecular Cell …, 2022 - nature.com
Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Niche stiffness underlies the ageing of central nervous system progenitor cells

…, DH Rowitch, K Franze, RJM Franklin, KJ Chalut - Nature, 2019 - nature.com
Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell
and progenitor cell populations 1 . One example is the deterioration of the regenerative …

[PDF][PDF] The actin cortex: a bridge between cell shape and function

KJ Chalut, EK Paluch - Developmental cell, 2016 - cell.com
The cortical actin network controls many animal cell shape changes by locally modulating
cortical tension. Recent work has provided insight into cortex components and regulators. …

[PDF][PDF] Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells

KJ Chalut, M Höpfler, F Lautenschläger, L Boyde… - Biophysical journal, 2012 - cell.com
The interplay between epigenetic modification and chromatin compaction is implicated in the
regulation of gene expression, and it comprises one of the most fascinating frontiers in cell …

[PDF][PDF] Myosin II activity softens cells in suspension

…, S Golfier, W Li, KJ Chalut, O Otto, J Elgeti, J Guck… - Biophysical journal, 2015 - cell.com
The cellular cytoskeleton is crucial for many cellular functions such as cell motility and wound
healing, as well as other processes that require shape change or force generation. Actin is …

Quantifying cellular differentiation by physical phenotype using digital holographic microscopy

KJ Chalut, AE Ekpenyong, WL Clegg… - Integrative …, 2012 - academic.oup.com
Although the biochemical changes that occur during cell differentiation are well-known, less
known is that there are significant, cell-wide physical changes that also occur. …

[PDF][PDF] Cell surface fluctuations regulate early embryonic lineage sorting

…, K Franze, E Hannezo, EK Paluch, J Nichols, KJ Chalut - Cell, 2022 - cell.com
In development, lineage segregation is coordinated in time and space. An important example
is the mammalian inner cell mass, in which the primitive endoderm (PrE, founder of the …