Soil microbiota represent one of the ancient evolutionary origins of antibiotic resistance and
have been proposed as a reservoir of resistance genes available for exchange with clinical …

Ancient and diverse antibiotic resistance genes (ARGs) have previously been identified
from soil 1 , 2 , 3 , including genes identical to those in human pathogens 4 . Despite the …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling
methods. The four most frequently used sequencing-based technologies are the bisulfite…

Antibiotic resistance is a dire clinical problem with important ecological dimensions. While
antibiotic resistance in human pathogens continues to rise at alarming rates, the impact of …

Emerging antibiotic resistance threatens human health. Gut microbes are an epidemiologically
important reservoir of resistance genes (resistome), yet prior studies indicate that the true …

Enzymes capable of inactivating tetracycline are paradoxically rare compared with enzymes
that inactivate other natural-product antibiotics. We describe a family of flavoenzymes, …

Lignin-derived (eg phenolic) compounds can compromise the bioconversion of
lignocellulosic biomass to fuels and chemicals due to their toxicity and recalcitrance. The lipid-…

Rates of infection with antibiotic-resistant bacteria have increased precipitously over the
past several decades, with far-reaching healthcare and societal costs. Recent evidence has …

The soil microbiome can produce, resist, or degrade antibiotics and even catabolize them.
While resistance genes are widely distributed in the soil, there is a dearth of knowledge …

10.7554/eLife.46540.001 CRISPR-Cas systems protect bacteria and archaea from phages
and other mobile genetic elements, which use small anti-CRISPR (Acr) proteins to overcome …