User profiles for Kevin J. Tracey
Kevin J. TraceyFeinstein Institute for Medical Research Verified email at northwell.edu Cited by 128268 |
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Vertebrates achieve internal homeostasis during infection or injury by balancing the
activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), …
activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), …
Sepsis definitions: time for change
The modern concept of sepsis has focused on the human response to invading organisms.
In 1991, a North American consensus conference introduced the idea that sepsis is the host’s …
In 1991, a North American consensus conference introduced the idea that sepsis is the host’s …
HMG-1 as a late mediator of endotoxin lethality in mice
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release
large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate …
large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate …
Reflex control of immunity
KJ Tracey - Nature Reviews Immunology, 2009 - nature.com
Inflammation can cause damage and even death. What controls this primitive and potentially
lethal innate immune response to injury and infection? Molecular and neurophysiological …
lethal innate immune response to injury and infection? Molecular and neurophysiological …
The inflammatory reflex
KJ Tracey - Nature, 2002 - nature.com
Inflammation is a local, protective response to microbial invasion or injury. It must be fine-tuned
and regulated precisely, because deficiencies or excesses of the inflammatory response …
and regulated precisely, because deficiencies or excesses of the inflammatory response …
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and
mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and …
mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and …
Shock and tissue injury induced by recombinant human cachectin
KJ Tracey, B Beutler, SF Lowry, J Merryweather… - Science, 1986 - science.org
Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated
macrophages, has been implicated as an important mediator of the lethal effect of …
macrophages, has been implicated as an important mediator of the lethal effect of …
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially
fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. …
fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. …
High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
MT Lotze, KJ Tracey - Nature Reviews Immunology, 2005 - nature.com
High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …
[HTML][HTML] Physiology and immunology of the cholinergic antiinflammatory pathway
KJ Tracey - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
Cytokine production by the immune system contributes importantly to both health and disease.
The nervous system, via an inflammatory reflex of the vagus nerve, can inhibit cytokine …
The nervous system, via an inflammatory reflex of the vagus nerve, can inhibit cytokine …