User profiles for Kevin J. Tracey

Kevin J. Tracey

Feinstein Institute for Medical Research
Verified email at northwell.edu
Cited by 128268

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

…, H Wang, N Abumrad, JW Eaton, KJ Tracey - Nature, 2000 - nature.com
Vertebrates achieve internal homeostasis during infection or injury by balancing the
activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), …

Sepsis definitions: time for change

JL Vincent, SM Opal, JC Marshall, KJ Tracey - The Lancet, 2013 - thelancet.com
The modern concept of sepsis has focused on the human response to invading organisms.
In 1991, a North American consensus conference introduced the idea that sepsis is the host’s …

HMG-1 as a late mediator of endotoxin lethality in mice

…, PE Molina, NN Abumrad, A Sama, KJ Tracey - Science, 1999 - science.org
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release
large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate …

Reflex control of immunity

KJ Tracey - Nature Reviews Immunology, 2009 - nature.com
Inflammation can cause damage and even death. What controls this primitive and potentially
lethal innate immune response to injury and infection? Molecular and neurophysiological …

The inflammatory reflex

KJ Tracey - Nature, 2002 - nature.com
Inflammation is a local, protective response to microbial invasion or injury. It must be fine-tuned
and regulated precisely, because deficiencies or excesses of the inflammatory response …

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

…, H Yang, L Ulloa, Y Al-Abed, CJ Czura, KJ Tracey - Nature, 2003 - nature.com
Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and
mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and …

Shock and tissue injury induced by recombinant human cachectin

KJ Tracey, B Beutler, SF Lowry, J Merryweather… - Science, 1986 - science.org
Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated
macrophages, has been implicated as an important mediator of the lethal effect of …

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

KJ Tracey, Y Fong, DG Hesse, KR Manogue, AT Lee… - Nature, 1987 - nature.com
Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially
fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. …

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

MT Lotze, KJ Tracey - Nature Reviews Immunology, 2005 - nature.com
High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

[HTML][HTML] Physiology and immunology of the cholinergic antiinflammatory pathway

KJ Tracey - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
Cytokine production by the immune system contributes importantly to both health and disease.
The nervous system, via an inflammatory reflex of the vagus nerve, can inhibit cytokine …