User profiles for Kevin Litchfield
 | Kevin LITCHFIELDResearch Leader - Isomorphic Labs (Alphabet company), Honorary Group Leader - UCL Verified email at google.com Cited by 8278 |
[PDF][PDF] Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …
[HTML][HTML] Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours
K Litchfield, B Summersgill, S Yost, R Sultana… - Nature …, 2015 - nature.com
Testicular germ cell tumours (TGCTs) are the most common cancer in young men. Here we
perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the …
perform whole-exome sequencing (WES) of 42 TGCTs to comprehensively study the …
Genomic evolution and chemoresistance in germ-cell tumours
Germ-cell tumours (GCTs) are derived from germ cells and occur most frequently in the testes
1 , 2 . GCTs are histologically heterogeneous and distinctly curable with chemotherapy 3 . …
1 , 2 . GCTs are histologically heterogeneous and distinctly curable with chemotherapy 3 . …
[HTML][HTML] Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis
Background The focus of tumour-specific antigen analyses has been on single nucleotide
variants (SNVs), with the contribution of small insertions and deletions (indels) less well …
variants (SNVs), with the contribution of small insertions and deletions (indels) less well …
[PDF][PDF] Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal
The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically
studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited …
studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited …
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
Genome-wide association studies (GWAS) have transformed understanding of susceptibility
to testicular germ cell tumors (TGCTs), but much of the heritability remains unexplained. …
to testicular germ cell tumors (TGCTs), but much of the heritability remains unexplained. …
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-…
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-…
[PDF][PDF] Tracking cancer evolution reveals constrained routes to metastases: TRACERx renal
Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes
that have not been systematically studied to date. Here, we analyzed 575 primary and 335 …
that have not been systematically studied to date. Here, we analyzed 575 primary and 335 …
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
[PDF][PDF] Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi… - Cancer cell, 2018 - cell.com
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …