[HTML][HTML] Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
guidelines for the definition and interpretation of cell death from morphological, biochemical, …
Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
[HTML][HTML] DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
Inactivation of cell death is a major step in tumor development, and p53, a tumor suppressor
frequently mutated in cancer, is a critical mediator of cell death. While a role for p53 in …
frequently mutated in cancer, is a critical mediator of cell death. While a role for p53 in …
Molecular definitions of autophagy and related processes
Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms. Moreover…
has been characterized with ever increasing precision in multiple model organisms. Moreover…
Autophagy in malignant transformation and cancer progression
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation. …
such a homeostatic activity constitutes a robust barrier against malignant transformation. …
p53 and metabolism
KH Vousden, KM Ryan - Nature Reviews Cancer, 2009 - nature.com
Although metabolic alterations have been observed in cancer for almost a century, only
recently have the mechanisms underlying these changes been identified and the importance of …
recently have the mechanisms underlying these changes been identified and the importance of …
Role of NF-κB in p53-mediated programmed cell death
KM Ryan, MK Ernst, NR Rice, KH Vousden - Nature, 2000 - nature.com
The tumour suppressor p53 inhibits cell growth through activation of cell-cycle arrest and
apoptosis 1 , and most cancers have either mutation within the p53 gene or defects in the …
apoptosis 1 , and most cancers have either mutation within the p53 gene or defects in the …
Regulation and function of the p53 tumor suppressor protein
KM Ryan, AC Phillips, KH Vousden - Current opinion in cell biology, 2001 - Elsevier
Loss of the p53 tumor suppressor pathway contributes to the development of most human
cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant …
cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant …
[HTML][HTML] Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular
homeostasis and cell viability. Autophagy is the principal mechanism that mediates the …
homeostasis and cell viability. Autophagy is the principal mechanism that mediates the …
Compound copper chalcogenide nanocrystals
This review captures the synthesis, assembly, properties, and applications of copper chalcogenide
NCs, which have achieved significant research interest in the last decade due to their …
NCs, which have achieved significant research interest in the last decade due to their …