Variability in the size of single postsynaptic responses is a feature of most central neurons,
although the source of this variability is not completely understood. The dominant source of …

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely
trafficked to septal cholinergic neurons, providing a potential mechanism for modulating …

In the piriform cortex, individual odorants activate a unique ensemble of neurons that are
distributed without discernable spatial order. Piriform neurons receive convergent excitatory …

We have developed a biophysically realistic model of receptor activation at an idealized
central glutamatergic synapse that uses Monte Carlo techniques to simulate the stochastic …

Within the olfactory system, information flow from the periphery onto output mitral cells (MCs)
of the olfactory bulb (OB) has been thought to be mediated by direct synaptic inputs from …

The cortex organizes sensory information to enable discrimination and generalization 1 , 2 ,
3 – 4 . As systematic representations of chemical odour space have not yet been described …

10.7554/eLife.22630.001 The ability to represent both stimulus identity and intensity is
fundamental for perception. Using large-scale population recordings in awake mice, we find …

INTRODUCTION Objects can appear remarkably stable despite the often fickle cues they
provide to our senses. For instance, a foraging mouse can identify and locate a piece of …

Single-cell genetic manipulation is expected to substantially advance the field of systems
neuroscience. However, existing gene delivery techniques do not allow researchers to …

Olfaction is required at birth for survival; however, little is known about the maturation of
olfactory cortical circuits. Here we show that in vivo sensory experience mediates the …