The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model(s) being used. There are …

Discovered as antiviral cytokines, interferons (IFNs) are now also recognized for their
capacity to inhibit the growth of malignant cells via activation of programmed cell death, better …

The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well‐documented
in vitro. Yet evidence of IFN‐activated STAT2 as having tumor suppressor function in …

The immune system of the gastrointestinal (GI) tract manages the significant task of
recognizing and eliminating pathogens while maintaining tolerance of commensal bacteria. …

Late-onset Alzheimer’s disease (AD; LOAD) is the most common human neurodegenerative
disease, however, the availability and efficacy of disease-modifying interventions is …

Background Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia
worldwide. To date, animal models of Alzheimer’s have focused on rare familial mutations, …

INTRODUCTION: Restrictions on existing APOE mouse models have impacted research
towards understanding the strongest genetic risk factor contributing to Alzheimer’s disease (AD) …

Background Molecular characterization of late-onset Alzheimer’s disease (LOAD), the
leading cause of age-related dementia, has revealed transcripts, proteins, and pathway …

TLR-stimulated cross-presentation by conventional dendritic cells (cDCs) is important in
host defense and antitumor immunity. We recently reported that cDCs lacking the type I IFN …

The mechanisms by which the gut luminal environment is disturbed by the immune system
to foster pathogenic bacterial growth and survival remain incompletely understood. Here, we …