Endogenous retroviruses (ERVs) are ancient viral elements that have accumulated in the
genome through retrotransposition events. Although they have lost their ability to transpose, …

Transposable elements (TEs) are mobile genetic elements that make up a large fraction of
mammalian genomes. While select TEs have been co-opted in host genomes to have function…

Metabolic diseases such as obesity and diabetes are complex diseases resulting from multiple
genetic and environmental factors, such as diet and activity levels. These factors are well …

In this study Shin and colleagues investigate the role of the posttranslational modification of
the DNA methyltransferase by covalent linkage of the N-Acetylglucosamine (O-GlcNAc). The …

Transposable elements (TEs) are mobile genetic elements that make up a large fraction of
mammalian genomes. While select TEs have been co-opted in host genomes to have function…

Early-life factors, including nutrition, shape long-term health outcomes. Despite the essential
role of lactation in maternal nutritional support, the influence of epigenetic factors on …

… The retelling of the tale mathematically by Kevin Costello is a beautiful tour de force.—Dennis
Sullivan This book is quite a remarkable contribution. It should make perturbative quantum …

The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA
methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein …

The production of O-GlcNAc for protein O-GlcNAcylation is highly tuned to the metabolic
state of the cell and thus can serve as a nutrient sensor responding to changes in metabolic …

BACKGROUND Regulatory innovation is central to the evolution of species. Different nutritional
sources are one environmental pressure that can lead to selection for novel regulatory …