Oxidation is known to affect the structure, activity, and rate of degradation of proteins, and is
believed to contribute to a variety of pathological conditions. Metal‐catalyzed oxidation (MCO…

Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions ranging …

Increased flux through the hexosamine biosynthesis pathway has been implicated in the
development of glucose-induced insulin resistance and may promote the modification of certain …

Exosomes are membrane vesicles that are secreted by cells upon fusion of multivesicular
bodies with the plasma membrane. Exosomal proteomics has emerged as a powerful …

The role of vertebrate histone proteins or histone derived peptides as innate immune effectors
has only recently been appreciated. In this study, high levels of core histone proteins H2A, …

Abstract Characterization of exosomal cargo is of significant interest because this cargo can
provide clues to exosome biogenesis, targeting, and cellular effects and may be a source of …

Purpose.: The accumulation of lipofuscin in the RPE is a hallmark of aging in the eye. The
best characterized component of lipofuscin is A2E, a bis-retinoid byproduct of the normal …

Matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS) has the
ability to provide an enormous amount of information on the abundances and spatial …

purpose. To develop a protocol for MALDI (matrix-assisted laser desorption ionization) imaging
mass spectrometry for mapping the distributions of α-crystallin and its modified forms in …

purpose. Aquaporin 0 (AQP0), the most abundant membrane protein in the lens, is a water-permeable
channel, has a role in fiber cell adhesion, and is essential for fiber cell structure …