[HTML][HTML] Genome-wide association studies of brain imaging phenotypes in UK Biobank
The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
this, we carried out genome-wide association studies of 3,144 functional and structural brain …
[HTML][HTML] The UK Biobank resource with deep phenotyping and genomic data
…, C Freeman, D Petkova, G Band, LT Elliott, K Sharp… - Nature, 2018 - nature.com
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic
data collected on approximately 500,000 individuals from across the United Kingdom, aged …
data collected on approximately 500,000 individuals from across the United Kingdom, aged …
Haplotype estimation for biobank-scale data sets
The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together
with extensive phenotypic and lifestyle information. We present a new phasing method, …
with extensive phenotypic and lifestyle information. We present a new phasing method, …
Genome-wide genetic data on~ 500,000 UK Biobank participants
…, C Freeman, D Petkova, G Band, LT Elliott, K Sharp… - BioRxiv, 2017 - biorxiv.org
The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across
the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and …
the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and …
An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank
UK Biobank is a major prospective epidemiological study, including multimodal brain
imaging, genetics and ongoing health outcomes. Previously, we published genome-wide …
imaging, genetics and ongoing health outcomes. Previously, we published genome-wide …
UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits
…, D Wells, S Selzam, I Peneva, R Moore, K Sharp… - MedRxiv, 2022 - medrxiv.org
We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set
of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
[HTML][HTML] A Genotype-Phenotype Study of High-Resolution FMR1 Nucleic Acid and Protein Analyses in Fragile X Patients with Neurobehavioral Assessments
…, K Javanmardi, J Kemppainen, A Hadd, K Sharp… - Brain sciences, 2020 - mdpi.com
Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene, which encodes a
protein with a critical role in synaptic plasticity. The molecular abnormality underlying FMR1 …
protein with a critical role in synaptic plasticity. The molecular abnormality underlying FMR1 …
Wildfire mitigation plans in power systems: A literature review
…, F Qiu, N Fan, K Sharp - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Some of the deadliest wildfires in the US, such as California’s 2018 wildfires, have been
ignited by power systems. In an effort to prevent and minimize the ignition of wildfires, or control …
ignited by power systems. In an effort to prevent and minimize the ignition of wildfires, or control …
Enhanced brain imaging genetics in UK Biobank
UK Biobank is a major prospective epidemiological study that is carrying out detailed
multimodal brain imaging on 100,000 participants, and includes genetics and ongoing health …
multimodal brain imaging on 100,000 participants, and includes genetics and ongoing health …
Identification of rfk-1, a Meiotic Driver Undergoing RNA Editing in Neurospora
…, P Manitchotpisit, DW Brown, KJ Sharp… - Genetics, 2019 - academic.oup.com
A Neurospora meiotic drive element known as Spore killer-2 (Sk-2) achieves biased transmission
through sexual reproduction by killing siblings that inherit a competing allele... Sk-2 is …
through sexual reproduction by killing siblings that inherit a competing allele... Sk-2 is …