Amyloid disorders cause debilitating illnesses through the formation of toxic protein aggregates.
The mechanisms of amyloid toxicity and the nature of species responsible for mediating …

The formation of amyloid fibres is a hallmark of amyloid disorders. Nevertheless, the lack of
correlation between fibre load and disease as observed, for example, in Alzheimer's disease, …

RAS mutations are the most common oncogenic drivers across human cancers, but there
remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable …

Although the molecular mechanisms underlying the pathology of amyloidoses are not well
understood, the interaction between amyloid proteins and cell membranes is thought to play a …

Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an
otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the …

Amyloid fibril accumulation is a pathological hallmark of several devastating disorders,
including Alzheimer's disease, prion diseases, type II diabetes, and others. Although the …

Amyloid diseases are a group of protein misfolding disorders characterised by the formation
of highly ordered filamentous assemblies known as amyloid fibrils. Soluble aggregation …

Ras proteins are small GTPases that are mutationally activated in around 30% of all human
cancers. Oncogenic mutations in Ras trigger uncontrolled cellular differentiation and division …

A damaging belief exists that to become a victim of sexual violence, victims must be deemed
sexually desirable. As a result, sexual violations where the victims are individuals whom …

Background In phase 3 MODIFY I/II trials, bezlotoxumab significantly reduced recurrence of
Clostridioides (Clostridium) difficile infection (rCDI) over 12 weeks. Choice of CDI …