Progressive functional decline in the epilepsies is largely unexplained. We formed the
ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, …

A cerebral network comprising precuneus, medial frontal, and temporoparietal cortices is
less active both during goal‐directed behavior and states of reduced consciousness than …

We used simultaneous EEG and functional MRI (EEG–fMRI) to study generalized spike
wave activity (GSW) in idiopathic and secondary generalized epilepsy (SGE). Recent studies …

Using continuous EEG-correlated fMRI, we investigated the Blood Oxygen Level Dependent
(BOLD) signal correlates of interictal epileptic discharges (IEDs) in 63 consecutively …

Importance Efficacy of cannabidiol has been demonstrated in seizures associated with
Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in …

Purpose: To illustrate a functional interpretation of blood oxygen level–dependent (BOLD)
signal changes associated with generalized spike‐and‐wave discharges in patients with …

The EEG/MEG signal is generated primarily by the summation of the post-synaptic potentials
of cortical principal cells. At a microcircuit level, these glutamatergic principal cells are …

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis,
we integrated neuroimaging and connectome analysis to identify network …

The epilepsies are commonly accompanied by widespread abnormalities in cerebral white
matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data …

Background Generalised spike wave (GSW) discharges are the electroencephalographic (EEG)
hallmark of absence seizures, clinically characterised by a transitory interruption of …