User profiles for Kieran I. Chacko

Kieran Chacko

Icahn Institute for Genomics & Multiscale Biology
Verified email at icahn.mssm.edu
Cited by 180

Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection

DR Altman, MJ Sullivan, KI Chacko… - Infection and …, 2018 - Am Soc Microbiol
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when
treatment conditions are optimal according to experimental protocols. Adapted subclones, …

A complete genome screening program of clinical methicillin-resistant Staphylococcus aureus isolates identifies the origin and progression of a neonatal intensive …

MJ Sullivan, DR Altman, KI Chacko… - Journal of clinical …, 2019 - Am Soc Microbiol
Whole-genome sequencing (WGS) of Staphylococcus aureus is increasingly used as part of
infection prevention practices. In this study, we established a long-read technology-based …

[HTML][HTML] PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks

…, TR Pak, A Obla, AC Dupper, KI Chacko… - Genome Medicine, 2020 - Springer
Background Whole-genome sequencing (WGS) is increasingly used to map the spread of
bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread …

Genetic basis of emerging vancomycin, linezolid, and daptomycin heteroresistance in a case of persistent Enterococcus faecium bacteremia

KI Chacko, MJ Sullivan, C Beckford… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Whole-genome sequencing was used to examine a persistent Enterococcus faecium bacteremia
that acquired heteroresistance to three antibiotics in response to prolonged multidrug …

Mce3R stress-resistance pathway is vulnerable to small-molecule targeting that improves tuberculosis drug activities

X Yang, T Yuan, R Ma, KI Chacko, M Smith… - ACS Infectious …, 2019 - ACS Publications
One-third of the world’s population carries Mycobacterium tuberculosis (Mtb), the infectious
agent that causes tuberculosis (TB), and every 17 s someone dies of TB. After infection, Mtb …

[HTML][HTML] Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection

…, D Nadkarni, L Fox, A Mills, A Obla, KI Chacko… - BMC Infectious …, 2022 - Springer
Background Healthcare-associated infections pose a potentially fatal threat to patients
worldwide and Staphylococcus aureus is one of the most common causes of healthcare-…

Blurred Molecular Epidemiological Lines Between the Two Dominant Methicillin-Resistant Staphylococcus aureus Clones

AC Dupper, MJ Sullivan, KI Chacko… - Open forum …, 2019 - academic.oup.com
Background Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening
infections in both community and hospital settings and is a leading cause of health care–…

Estimating local costs associated with Clostridium difficile infection using machine learning and electronic medical records

TR Pak, KI Chacko, T O'Donnell… - infection control & …, 2017 - cambridge.org
BACKGROUNDReported per-patient costs of Clostridium difficile infection (CDI) vary by 2
orders of magnitude among different hospitals, implying that infection control officers need …

Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations

AG Mills, AC Dupper, KI Chacko… - Antimicrobial …, 2023 - cambridge.org
This case–control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA)
bacteremia with vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 …

[HTML][HTML] Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient

…, KV Singh, D Altman, T Pak, J Dutta, K Chacko… - PloS one, 2017 - journals.plos.org
In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site
and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus …