User profiles for Kieran I. Chacko
Kieran ChackoIcahn Institute for Genomics & Multiscale Biology Verified email at icahn.mssm.edu Cited by 180 |
Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when
treatment conditions are optimal according to experimental protocols. Adapted subclones, …
treatment conditions are optimal according to experimental protocols. Adapted subclones, …
A complete genome screening program of clinical methicillin-resistant Staphylococcus aureus isolates identifies the origin and progression of a neonatal intensive …
Whole-genome sequencing (WGS) of Staphylococcus aureus is increasingly used as part of
infection prevention practices. In this study, we established a long-read technology-based …
infection prevention practices. In this study, we established a long-read technology-based …
[HTML][HTML] PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks
Background Whole-genome sequencing (WGS) is increasingly used to map the spread of
bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread …
bacterial and viral pathogens in nosocomial settings. A limiting factor for more widespread …
Genetic basis of emerging vancomycin, linezolid, and daptomycin heteroresistance in a case of persistent Enterococcus faecium bacteremia
KI Chacko, MJ Sullivan, C Beckford… - Antimicrobial Agents …, 2018 - Am Soc Microbiol
Whole-genome sequencing was used to examine a persistent Enterococcus faecium bacteremia
that acquired heteroresistance to three antibiotics in response to prolonged multidrug …
that acquired heteroresistance to three antibiotics in response to prolonged multidrug …
Mce3R stress-resistance pathway is vulnerable to small-molecule targeting that improves tuberculosis drug activities
One-third of the world’s population carries Mycobacterium tuberculosis (Mtb), the infectious
agent that causes tuberculosis (TB), and every 17 s someone dies of TB. After infection, Mtb …
agent that causes tuberculosis (TB), and every 17 s someone dies of TB. After infection, Mtb …
[HTML][HTML] Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection
Background Healthcare-associated infections pose a potentially fatal threat to patients
worldwide and Staphylococcus aureus is one of the most common causes of healthcare-…
worldwide and Staphylococcus aureus is one of the most common causes of healthcare-…
Blurred Molecular Epidemiological Lines Between the Two Dominant Methicillin-Resistant Staphylococcus aureus Clones
AC Dupper, MJ Sullivan, KI Chacko… - Open forum …, 2019 - academic.oup.com
Background Methicillin-resistant Staphylococcus aureus (MRSA) causes life-threatening
infections in both community and hospital settings and is a leading cause of health care–…
infections in both community and hospital settings and is a leading cause of health care–…
Estimating local costs associated with Clostridium difficile infection using machine learning and electronic medical records
BACKGROUNDReported per-patient costs of Clostridium difficile infection (CDI) vary by 2
orders of magnitude among different hospitals, implying that infection control officers need …
orders of magnitude among different hospitals, implying that infection control officers need …
Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations
AG Mills, AC Dupper, KI Chacko… - Antimicrobial …, 2023 - cambridge.org
This case–control study of 25 cases with methicillin-resistant Staphylococcus aureus (MRSA)
bacteremia with vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 …
bacteremia with vancomycin minimum inhibitory concentration (MIC) ≥ 2 µg/mL and 391 …
[HTML][HTML] Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient
In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site
and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus …
and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus …