Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic
context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides …

To address the long-known relationship between supernumerary centrosomes and cancer,
we have generated a transgenic mouse that permits inducible expression of the master …

The epidermis is maintained by multiple stem cell populations whose progeny differentiate
along diverse, and spatially distinct, lineages. Here we show that the transcription factor …

Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular
basis for this heterogeneity, we performed genome-wide pooled RNA interference screens …

In human skin the interface between the epidermis and dermis is not flat, but undulates. The
dimensions of the undulations change as a function of age and disease. Epidermal stem cell …

Ribosome-associated mRNA quality control mechanisms ensure the fidelity of protein
translation 1 , 2 . Although these mechanisms have been extensively studied in yeast, little is …

Permanent stop-and-shop large-scale mouse mutant resources provide an excellent
platform to decipher tissue phenogenomics. Here we analyse skin from 538 knockout mouse …

10.7554/eLife.27356.001 Epidermal homeostasis depends on a balance between stem cell
renewal and terminal differentiation. The transition between the two cell states, termed …

The epidermis is the outermost layer of skin that acts as a barrier to protect the body from the
external environment and to control water and heat loss. This barrier function is established …