Complementary DNA's that encode an adenylyl cyclase were isolated from a bovine brain
library. Most of the deduced amino acid sequence of 1134 residues is divisible into two …

Yersinia species use a variety of type III effector proteins to target eukaryotic signaling
systems. The effector YopJ inhibits mitogen-activated protein kinase (MAPK) and the nuclear …

Homologs of the Yersinia virulence effector YopJ are found in both plant and animal bacterial
pathogens, as well as plant symbionts. These YopJ family members were shown to act as …

When ectopically expressed in animal cells, cytokine response modifier A (CrmA), a product
of the cowpox virus, prevents programmed cell death initiated by a variety of stimuli. Since …

Genetic analyses of Caenorhabditis elegans has identified three genes that function in the
regulation of nematode cell death. Mammalian homologs of two of these genes, ced-9 and …

Phylogenetic analysis of the CED-3/ICE family of cysteine proteases suggests the existence
of a subfamily most related to the Caenorhabditis elegans death gene ced-3 and includes …

The bacterial pathogen Yersinia uses a type III secretion system to inject several virulence
factors into target cells. One of the Yersinia virulence factors, YopJ, was shown to bind directly …

Apoptosis of human endothelial cells after growth factor deprivation is associated with rapid
and dramatic up-regulation of cyclin A–associated cyclin-dependent kinase 2 (cdk2) activity. …

We have recently demonstrated that mutation of the transforming growth factor-β (TGF-β)
receptor type II (RII) gene is characteristic of colon cancers exhibiting microsatellite instability or …

The Vibrio parahaemolyticus type III effector VopS is implicated in cell rounding and the
collapse of the actin cytoskeleton by inhibiting Rho guanosine triphosphatases (GTPases). We …