Experimental models to study intestinal microbes–mucus interactions in health and disease

…, B Chassaing, M Desvaux, K De Paepe… - FEMS microbiology …, 2019 - academic.oup.com
A close symbiotic relationship exists between the intestinal microbiota and its host. A critical
component of gut homeostasis is the presence of a mucus layer covering the gastrointestinal …

[HTML][HTML] Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease

T Gryp, K De Paepe, R Vanholder, FM Kerckhof… - Kidney international, 2020 - Elsevier
Chronic kidney disease (CKD) is characterized by accumulation of protein-bound uremic
toxins such as p-cresyl sulfate, p-cresyl glucuronide, indoxyl sulfate and indole-3-acetic acid, …

[HTML][HTML] Postbiotics and their health modulatory biomolecules

E Scott, K De Paepe, T Van de Wiele - Biomolecules, 2022 - mdpi.com
Postbiotics are a new category of biotics that have the potential to confer health benefits but,
unlike probiotics, do not require living cells to induce health effects and thus are not subject …

Microbial succession during wheat bran fermentation and colonisation by human faecal microbiota as a result of niche diversification

K De Paepe, J Verspreet, CM Courtin… - The ISME …, 2020 - academic.oup.com
… Faecal slurries were prepared as described by De Paepe et al. [… attached microorganisms,
as described by De Paepe et al. [40]. … We would like to thank Jolien De Paepe for critically …

Mucin degradation niche as a driver of microbiome composition and Akkermansia muciniphila abundance in a dynamic gut model is donor independent

F Van Herreweghen, K De Paepe… - FEMS microbiology …, 2018 - academic.oup.com
… The authors would like to thank Jana De Bodt and Tim Lacoere for the technical support,
Kim de Paepe for the support in analyzing the Illumina data and for the statistical support. …

Inter‐individual differences determine the outcome of wheat bran colonization by the human gut microbiome

K De Paepe, FM Kerckhof, J Verspreet… - Environmental …, 2017 - Wiley Online Library
Gut microbiota research reveals a vital role for the luminal and mucosal gut microbiota in
human health. Fewer studies, however, have characterized the microbiome associated with …

Efficacy and safety of spore-forming probiotics in the treatment of functional dyspepsia: a pilot randomised, double-blind, placebo-controlled trial

L Wauters, H Slaets, K De Paepe… - The Lancet …, 2021 - thelancet.com
Background Current treatments for functional dyspepsia have limited efficacy or present
safety issues. We aimed to assess spore-forming probiotics in functional dyspepsia as …

[PDF][PDF] Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage

…, K Klebermaß-Schrehof, K De Paepe, T Van de Wiele… - Cell Host & Microbe, 2021 - cell.com
Premature infants are at substantial risk for suffering from perinatal white matter injury.
Though the gut microbiota has been implicated in early-life development, a detailed …

Bio-electrochemical COD removal for energy-efficient, maximum and robust nitrogen recovery from urine through membrane aerated nitrification

J De Paepe, K De Paepe, F Gòdia, K Rabaey… - Water Research, 2020 - Elsevier
Resource recovery from source-separated urine can shorten nutrient cycles on Earth and is
essential in regenerative life support systems for deep-space exploration. In this study, a …

[HTML][HTML] Gut microbiota response to in vitro transit time variation is mediated by microbial growth rates, nutrient use efficiency and adaptation to in vivo transit time

…, V Goethals, J Raes, T Van de Wiele, K De Paepe - Microbiome, 2023 - Springer
Background Transit time is an important modulator of the human gut microbiome. The
inability to modify transit time as the sole variable hampers mechanistic in vivo microbiome …